Name: PD-160725 2-hydroxyethanesulfonate
Brand: Alomone Labs
SKU: P-280

Cat #: P-280

Alternative Name PD-160725 isethionate salt

Lyophilized Powder yes

Bioassay Tested

Source Synthetic

MW: 444.46

Purity: >98%

Effective concentration 0.1-100 µM.

Structure

Chemical name 2-hydroxyethanesulfonic acid;6-methyl-7-nitro-5-(piperidin-1-ylmethyl)-1,4-dihydroquinoxaline-2,3-dione.

Molecular formula C₁₇H₂₄N₄O₈S.

CAS No.: 1262769-92-5

PubChem CID 71312022

Activity PD-160725 2-hydroxyethanesulfonate is an AMPA receptor antagonist.

Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Solubility Up to 20 mM in H₂O (slowly, clear yellow solution). Centrifuge all products before reconstitution (10000 x g 5 min).

Storage of solutions Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted stock solutions.

Our bioassay

Alomone Labs PD-160725 2-hydroxyethanesulfonate inhibits GluA1 channels expressed in Xenopus oocytes.
Time course of GluA1 currents, activated by a continuous application (top dotted line) of 1 µM glutamate, and reversibly inhibited by 2 µM and 10 µM PD-160725 2-hydroxyethanesulfonate (#P-280), as indicated (bars), at a holding potential of -80 mV.

Scientific background

PD-160725 2-hydroxyethanesulfonate is an AMPA receptor antagonist. Antagonists of AMPA receptors are good candidates for potential treatment of several neurological disorders including epilepsy, stroke and amyotrophic lateral sclerosis^1,2.

The ionotropic glutamate AMPA receptors (AMPARs) are the primary receptors that mediate fast excitatory synaptic transmission in the mammalian brain. The majority of this transmission in the mammalian central nervous system is mediated by the release of glutamate from the presynaptic terminal and its binding to glutamate receptors on the postsynaptic membrane².

Target AMPA receptors

Lyophilized Powder

Last update: 06/11/2022

For research purposes only, not for human use

Specifications

Citations

Applications

Scientific Background

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Order Summary

Certificate of Analysis

PD-160725 2-hydroxyethanesulfonate

Specifications

Citations

Applications

Scientific Background

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