This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
- Ragsdale, D.S. et al. (1991) Mol. Pharmacol. 40, 756.
- Alomone Labs Phenytoin inhibits NaV1.2 channel currents in Xenopus oocytes.A. Time course of current reversible inhibition by 50 and 250 µM Phenytoin (#P-235), as measured at peak current amplitude. Currents were elicited by a voltage step protocol from a holding potential of -60 mV to -10 mV delivered every 10 seconds. B. Example traces of current responses before and during 50 and 250 µM Phenytoin application.
Phenytoin is an anticonvulsant drug used in the treatment of grand mal and psychomotor epilepsy and protects against convulsions that occur during or after neurosurgery or due to severe head trauma. It is also administered for the treatment of trigeminal neuralgia, and certain psychoses and can be applied in the treatment of cardiac arrhythmia, digital intoxication, and myocardial infarction. In dermatology this drug is being used to treating ulcers and epidermolysis bullosa1,2.
Phenytoin has also been shown to block neuronal NaV channels3.
Phenytoin (#P-235) is a highly pure, synthetic, and biologically active compound.