Renal Adrenoceptor Antibody Explorer Kit

A Screening Package of Renal Adrenoceptor Antibodies Economically Priced
  • Lyophilized Powder
  • Antigen Incl.
Cat #: AK-650
Last update: 24/01/2020

Renal Adrenoceptor Antibody Explorer Kit (#AK-650) is a budget friendly screening package.

For research purposes only, not for human use

Scientific Background

Scientific Background
    • The kidneys play a pivotal role in human physiology as they regulate heart and fluid homeostasis. They do so by regulating blood salt and mineral concentrations. This instrumental property of the kidneys is mediated by a small, yet very sophisticated functional unit, namely the nephron that filters unnecessary blood solutes into the urine while all necessary ions are carefully retained into the blood circulation. This "in and out" transition of ions across the vasculature is mediated by a battery of transmembrane protein-channels that facilitates the passage of solutes into and out of the blood circulation.

      Adrenergic receptors are G-protein coupled receptors that mediate adrenaline and noradrenaline actions. To date, this family contains nine different gene products that are generally classified into alpha- and beta-adrenergic receptors (αAR and βAR)1. Members of the αAR are further divided into α1AR and α2AR that regulate vascular tone, sodium absorption and renal filtration rate. Members of the βAR, like β1AR and β2AR use cAMP as a second messenger to stimulate renin and therefore regulate blood hemodynamics2.

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