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This product is freeze dried. All water molecules have been removed.
The activity of this product has been verified and approved by our professional team.
This lyophilized product is shipped at room temperature. Please see its certificate of analysis for further storage instructions.
Use code: new-yl30-18
Valid until January 31st, 2018.
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Ro 25-6981 maleate is a highly potent and selective antagonist of GluN2B-containing NMDA receptors. The compound is an activity dependent antagonist of the receptor and demonstrates 5000 times fold selectivity for NR2B-containing receptors over NR2A-containing receptors1. Ro 25-6981 demonstrates an IC50 value of 0.009 µM towards NR2B-containing receptors and an IC50 of 52 µM towards NR2A-containing receptors1.
Ro 25-6981 protects cultured cortical neurons against glutamate toxicity and has anti-depressant and anti-inflammatory effects. It can suppress ischemic brain injury by regulating autophagy-related proteins during ischemia1,2.
NMDA receptors are composed of NR1 including eight different splice variants and NR2A-D. They are activated by the co-agonists glutamate and glycine1,2.
Alomone Labs is pleased to offer Ro 25-6981 maleate (#R-180).
- NMDA Receptor Antagonist Explorer Kit (#EK-350)
- Anti-NMDA Receptor 2B (GluN2B) (extracellular) (#AGC-003)
- Anti-NMDA Receptor 2B (GluN2B) (extracellular)-ATTO-594 (#AGC-003-AR)
- Pentamidine isethionate salt (#P-155)
- (±)-CPP (#C-175)
- Memantine hydrochloride (#M-145)
- D-AP5 (#D-145)
- Orphenadrine hydrochloride (#O-101)
- ZD 9379 (#Z-120)
- Eliprodil (#E-155)
- TCN 201 (#T-190)
- TCN 213 (#T-215)
- CNS-1102 (#C-305)
- Ro 8-4304 hydrochloride (#R-165)