Overview
Cat #:
R-125
Lyophilized Powder yes
Source Synthetic
MW: 357.43
Purity: >97%
Form Lyophilized powder.
Effective concentration 2-200 µM.
Structure
Chemical name 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione Rosiglitazone.
Molecular formula C18H19N3O3S.
CAS No.: 122320-73-4
Activity Rosiglitazone blocks KV4.3 channels with an IC50 = 24.5 μM1, Kir6.1 channels with as IC50 = 2 μM2 and blocks TRPM3 channels with IC50 = 5-10 μM3. At high concentrations Rosiglitazone activates TRPC5 channels3.
References-Activity
- Jeong, I. et al. (2011) Br. J. Pharmacol. 163, 510.
- Yu. L. et al. (2011) Br. J. Pharmacol. 164, 2064.
- Majeed, Y. et al. (2011) Mol. Pharmacol. 79, 1023.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 100 mM in DMSO . Centrifuge all product preparations before use (10000 x g for 1 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Rosiglitazone inhibits KV4.2 channels expressed in Xenopus oocytesA. Time course of KV4.2 peak current amplitude, elicited by 100 ms voltage step from holding potential of -100mV to 0mV, delivered every 10 seconds. Application of 100 µM Rosiglitazone (#R-125) blocks the KV4.2 current in a reversible manner (indicated by the horizontal bar). B. Representative current traces before and during application of 100 µM Rosiglitazone as indicated.
References - Scientific background
- Corona, J.C. et al. (2013) Exp. Neurol. 253, 16.
- Jeong, I. et al. (2011) Br. J. Pharmacol. 163, 510.
- Yu. L. et al. (2011) Br. J. Pharmacol. 164, 2064.
- Majeed, Y. et al. (2011) Mol. Pharmacol. 79, 1023.
Scientific background Rosiglitazone is known to activate Peroxisome proliferator-activated receptors (PPAR), ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily1. Data shows that Rosiglitazone blocks KV4.3 channels with an IC50 = 24.5 μM2, Kir6.1 channels with as IC50 = 2 μM3 and blocks TRPM3 channels with IC50 = 5-10 μM4. At high concentrations Rosiglitazone activates TRPC5 channels4.
Target KV4, Kir6.1, TRPM3, TRPC5 channels
Lyophilized Powder
Rosiglitazone (#R-125) is a highly pure, synthetic, and biologically active compound.
For research purposes only, not for human use
Last Update: 10/04/2023
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