(RS)-AMPA hydrobromide

AMPA, (+/-)-AMPA hydrobromide
An Agonist of AMPA Receptors
Cat #: A-266
Alternative Name AMPA, (+/-)-AMPA hydrobromide
  • Lyophilized Powder
  • Bioassay Tested
  • Source Synthetic
    MW: 267.07
    Purity: >95%
    Effective concentration 0.1-100 µM.
    Structure
    • (RS)-AMPA hydrobromide
    Chemical name 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid;hydrobromide.
    Molecular formula C7H11BrN2O4.
    CAS No.: 171259-81-7.
    PubChem CID 11957558
    Activity (RS)-AMPA is a selective AMPA receptor agonist1.
    References-Activity
    1. Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 50 mM in H2O. Centrifuge all product preparations before use (10,000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • (RS)-AMPA hydrobromide
      Alomone Labs (RS)-AMPA hydrobromide activates GluA1 channels expressed in Xenopus oocytes.
      Time course of current reversible activation by 0.1, 1 and 10 μM (RS)-AMPA hydrobromide (#A-266) followed by glutamate elicited currents (0.1, 1 and 10 μM, holding potential -80 mV) for comparison.
    References - Scientific background
    1. Howes, J.F. and Bell, C. (2007) Neurotherapeutics 4, 126.
    Scientific background

    Glutamate is the main excitatory neurotransmitter in the CNS. It is also involved in a variety of pathological conditions including epilepsy. Glutamate binds to a number of different receptor types such as the AMPA, kainate and NMDA receptors that relay its excitatory activity.

    (RS)-AMPA is a synthetic AMPA receptor agonist. It has an effective concentration of 0.1-100 µM. RS-AMPA selectively binds to AMPA receptors over the other types of glutamate receptors. RS-AMPA was found to elicit feeding behavior in a rat model while RS-AMPA’s enantiomer did not produce similar results1.

    Target AMPA receptors
    Last update: 24/01/2020

    (RS)-AMPA hydrobromide (#A-266) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use

    Applications

    Specifications

    Scientific Background

    Citations

    Citations
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