Overview
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Alomone Labs Taurine inhibits specific binding of Strychnine to rat spinal cord Strychnine-sensitive Glycine receptors.Percent inhibition of specific binding of 10 nM [3H]Strychnine to membranes from rat spinal cord was plotted against concentrations of Taurine (#T-130), (green circles) and of (-)-Strychnine (assay standard, black squares) and used to calculate IC50 and Ki values for Taurine (IC50 ≈ 397 µM, and Ki ≈ 224 µM).
- Wang, X. et al. (2016) Sci. Rep. 6, 21231.
- He, YU. et al. (2016) Anticancer Res. 36, 533.
- Rajendra, S. et al. (1995) EMBO J. 14, 2987.
Taurine (2-aminoethanesulfonic acid) is a β-amino acid, one of the most abundant free amino acids found in vertebrates. Taurine can be present in many tissues including brain, myocardium, and kidney. It plays an important role in several physiological processes including cardiac contraction, antioxidation, blunting of hypertension, bile acid conjugation, maintenance of calcium homeostasis, osmoregulation, and membrane stabilization.
Taurine acts as an endogenous partial agonist at the inhibitory glycine receptor (GlyR)1,2.
The glycine receptor is a member of the ligand-gated ion channel (LGIC) superfamily. The receptor mediates fast inhibitory neurotransmission in the mammalian spinal cord and parts of the brain3.
Taurine (#T-130) is a highly pure, synthetic, and biologically active compound.
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