A Potent Inhibitor of Sarcolasmic Reticulum Ca2+ ATPase
    Cat #: T-220
    Alternative Name DBHQ
  • Lyophilized Powder
  • Source Synthetic
    MW: 222.33
    Purity: >97%
    Effective concentration 1-10 μM.
      • tBuBHQ
    Chemical name 2,5-Ditert-butylbenzene-1,4-diol.
    Molecular formula C14H22O2.
    CAS No.: 88-58-4.
    Activity tBuBHQ is an inhibitor of the endoplasmic reticulum Ca2+-ATPase1.
    Shipping and storage Up to two years at room temperature.
    Solubility Ethanol or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to one week at 4°C.
    Protect from light.
    References - Scientific background
    • 1. Ershoff BH. (1969) Proc. Soc. Exp. Biol. Med. 131, 776.
    • 2. Tsukii. K. et al. (1996) Eur. J. Pharmacol298, 87.
      • tBuBHQ is a chemically synthesized compound1. It is widely used as a potent selective inhibitor of the sarcoplasmic reticulum Ca2+ ATPase pump (SERCA). The pump transfers Ca2+ from the cell cytosol to the endoplasmic reticulum lumen during muscle relaxation. Inhibition of SERCA by tBuBHQ causes a dose-dependent, sustained, and marked increase of cytoplasmatic Ca2+ and store-operated Ca2+ depletion1. tBuBHQ also causes superoxide anion production independently of Ca2+ secretion2.
    Target SERCA
    Last update: 24/01/2020

    tBuBHQ (#T-220) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use