Telmisartan

Micardis, Kinzalmono, Pritor
An Antagonist of Angiotensin Receptor Type-1
    Cat #: T-170
    Alternative Name Micardis, Kinzalmono, Pritor
  • Lyophilized Powder
  • Bioassay Tested
  • Source Synthetic
    MW: 514.6
    Purity: ≥99%
    Effective concentration 1-500 nM.
      • Telmisartan
    Chemical name 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid.
    Molecular formula C33H30N4O2.
    CAS No.: 144701-48-4.
    PubChem CID 65999
    Activity An antagonist of Angiotensin II type-1 receptor1.
      • Kumar, A.S. et al. (2010) Beilstein. J. Org. Chem. 6, 25.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
      • Telmisartan
        Alomone Labs Telmisartan inhibits the activation of AT1R expressed in CHO-K1-mt aequorin-Gα16 cells.
        Dose response curve for the inhibition of AT1R expressed in CHO-K1-mt aequorin-Gα16 cells. Ca2+ response, as detected by elevation in aequorin derived fluorescence following 0.04 nM Angiotensin II application, was inhibited by increasing concentrations of Telmisartan (T-170). 500 nM Telmisartan fully inhibited the activation by Angiotensin II.
    References - Scientific background
    • 1. Kurtz, T.W. et al. (2012) Vasc. Health Risk Manag. 8, 133.
    • 2. Griessner, M. et al. (2009) Anal. Bioanal. Chem. 395, 1937.
    • 3. Kumar, A.S. et al. (2010) Beilstein. J. Org. Chem. 6, 25.
      • Angiotensin II is responsible for vasoconstriction in the renin-angiotensin system. In addition to its direct effect on blood vessels it stimulates the synthesis and release of aldosterone and also promotes renal tubular reabsorption of sodium, resulting in water retention1.

        Telmisartan (Micardis, Kinzalmono, Pritor) is a synthetic antagonist of the Angiotensin II type 1 receptor. It has an effective concentration of 1-500 nM and an IC50 of 7.99 nM2. Telmisartan is mainly used for the treatment of essential hypertension but is also useful for other pathological conditions such as ischemic heart disease and urinary bladder diseases. Telmisartan was first synthesized by a costly and a rigorous series of chemical reactions. Today, synthesizing methods are safer and less expensive and also have an increased efficacy thus reducing the total cost of the product3.

    Target AT1R receptors
    Last update: 21/07/2019

    Telmisartan (#T-170) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use