This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
- Kumar, A.S. et al. (2010) Beilstein. J. Org. Chem. 6, 25.
- Alomone Labs Telmisartan inhibits the activation of AT1R expressed in CHO-K1-mt aequorin-Gα16 cells.Dose response curve for the inhibition of AT1R expressed in CHO-K1-mt aequorin-Gα16 cells. Ca2+ response, as detected by elevation in aequorin derived fluorescence following 0.04 nM Angiotensin II application, was inhibited by increasing concentrations of Telmisartan (T-170). 500 nM Telmisartan fully inhibited the activation by Angiotensin II.
Angiotensin II is responsible for vasoconstriction in the renin-angiotensin system. In addition to its direct effect on blood vessels it stimulates the synthesis and release of aldosterone and also promotes renal tubular reabsorption of sodium, resulting in water retention1.
Telmisartan (Micardis, Kinzalmono, Pritor) is a synthetic antagonist of the Angiotensin II type 1 receptor. It has an effective concentration of 1-500 nM and an IC50 of 7.99 nM2. Telmisartan is mainly used for the treatment of essential hypertension but is also useful for other pathological conditions such as ischemic heart disease and urinary bladder diseases. Telmisartan was first synthesized by a costly and a rigorous series of chemical reactions. Today, synthesizing methods are safer and less expensive and also have an increased efficacy thus reducing the total cost of the product3.
Telmisartan (#T-170) is a highly pure, synthetic, and biologically active compound.
- Anti-Angiotensin II Receptor Type-1 (extracellular) Antibody (#AAR-011)
- Anti-Angiotensin II Receptor Type-1 (extracellular)-ATTO-550 Antibody (#AAR-011-AO)
- Anti-Angiotensin II Receptor Type-2 (extracellular) Antibody (#AAR-012)
- Anti-Angiotensin II Receptor Type-2 (extracellular)-ATTO-488 Antibody (#AAR-012-AG)
- Angiotensin II (#GPA-100)
- Angiotensin III (#GPA-130)
- Eprosartan mesylate (#E-145)
- Azilsartan (#A-245)
- Olmesartan (#O-125)