Overview
Alternative Name Stelazine, Terfluzine, Triphthazine
Lyophilized Powder yes
Source Synthetic
MW: 480.4
Purity: >99%
Effective concentration 5-300 µM.
Structure
Chemical name 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;dihydrochloride.
Molecular formula C21H26Cl2F3N3S.
CAS No.: 440-17-5
PubChem CID 66064
Activity Trifluoperazine dihydrochloride blocks KV4.3 with an IC50 ~8 μM on cloned channels. It also inhibits D1 and D2 dopamine receptors1.
References-Activity
- Chae, Y.J. et al. (2014) Neurosci. Lett. 578, 159.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility 100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Our bioassay
Alomone Labs Trifluoperazine dihydrochloride blocks KV4. 3 channels expressed in Xenopus oocytes.A. Time course of KV4.3 current amplitude and inhibition by 100 and 300 µM Trifluoperazine dihydrochloride (#T-175). Currents were elicited by application of voltage step from a holding potential of -80 mV to 0 mV (150 msec), every 10 seconds. B. Superimposed example traces of current responses before and during perfusion of 100 and 300 µM Trifluoperazine dihydrochloride, as indicated.
Target KV4.3 channels, D1, D2 dopamine receptors
Lyophilized Powder
For research purposes only, not for human use
Last Update: 30/03/2021
Specifications
Citations
Citations
