Alomone Labs is pleased to offer the TRPA1 Channel Basic Research Pack (#ESB-302). The Research Pack contains all you need for TRPA1 research: A specific antibody recognizing TRPA1 at an extracellular domain of the protein and TRPA1 blockers and activators, all in one economical package!
The TRPA family is comprised of only one mammalian member, the TRPA1 (formerly named ANKTM1). TRPA1 is expressed in peripheral sensory neurons, where it is suggested to contribute to the detection of painful stimuli.1
Originally it was thought that TRPA channels sensed painfully cold temperatures2, but a more conservative description is that TRPA1 is sensitive to membrane/cytoskeletal perturbations by cold3-5 and perhaps stretch.6 In addition, it is sensitive to pungent natural compounds present in cinnamon oil, mustard oil, and wintergreen oil.
TRPA1 is also expressed in hair cells, where its role in sensing mechanical forces is still unclear and controversial.1
TRPA1 has similar structure as all TRP ion channel members, six transmembrane domains, intracellular N-and C-terminus. However, its N-terminus domain possesses 17 ankyrin repeats that might indicate its potential role as a mechanosensor.6,7
TRPA1 is expressed in nociceptive neurons expressing TRPV1 as well and might serve as a marker for poly-modal nociceptors.8
- Hill, K. and Schaefer, M. (2007) J. Biol. Chem. 282, 7145.
- Story, G.M. et al. (2003) Cell 112, 819.
- Bandell, M. et al. (2004) Neuron 41, 849.
- Jordt, S.E. et al. (2004) Nature 427, 260.
- Zurborg, S. et al. (2007) Nat. Neurosci. 10, 277.
- Corey, D.P. et al. (2004) Nature 432, 723.
- Sotomayor, M. et al. (2005) Structure 13, 669.
- Clapham, D.E. (2002) Science 295, 2228.