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Certificate of Analysis

  • Bioassay Tested

TRPA1 Channel Blocker Explorer Kit

A Screening Package of TRPA1 Channel Blockers Economically Priced

Cat #: EK-121
Size: 6 Vials
Form: Lyophilized

A 967079 Cat #: A-225

Size: 5 mg Source: Synthetic MW: 207.2 Purity: >99% (HPLC)
Effective concentration
10 nM - 100 µM.
Activity
A 967079 is a blocker of TRPA1 channels and has IC50 values of 67 and 289 nM at human and rat TRPA1 receptors respectively1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

AP-18 Cat #: A-250

Size: 5 mg Source: Synthetic MW: 209.7 Purity: >99% (HPLC)
Effective concentration
1-100 µM.
Activity
AP-18 has an IC50 of 3.1 and 4.5 μM for human and mouse TRPA1, respectively1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Chembridge-5861528 Cat #: C-235

Size: 5 mg Source: Synthetic MW: 369.4 Purity: >99%
Effective concentration
0.1-10 µM.
Activity
Chembridge-5861528 blocks TRPA1 channels and has an IC50 of 0.3 µM in rat-TRPA1 transfected HEK 293 cells1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

5-(N,N-Dimethyl)amiloride hydrochloride Cat #: D-165

Size: 5 mg Source: Synthetic MW: 294.1 Purity: >99% (HPLC)
Effective concentration
1-100 µM.
Activity
5-(N,N-Dimethyl)amiloride hydrochloride blocks TRPA1 channels with an IC50 of 80 µM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 50 mM in methanol. Centrifuge all product preparations before use (5,000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

HC-030031 Cat #: H-105

Size: 10 mg Source: Synthetic MW: 355.4 Purity: >99%
Effective concentration
1-100 µM.
Activity
HC-030031 has an IC50 of 5 μM for antagonizing formalin-evoked Ca2+ influx1. It blocks TRPA1 channels.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

ProTx-I Cat #: STP-400

Size: 0.1 mg MW: 3988 Da Purity: >98% (HPLC) Net peptide content: 100%
Origin
Synthetic peptide
Effective concentration
10-100 nM.
Activity
ProTx-I inhibits voltage-gated Ca2+ (CaV3.1), K+ (KV2.1), and all Na+ channels tested (NaV1.2, NaV1.5, NaV1.7 and NaV1.8). The toxin shifts the voltage-dependence of channel activation to more positive potentials.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to two weeks at 4°C or three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.

For research purposes only, not for human use
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