Overview
Cat #: EK-120
Size: 11 Vials
Form: Lyophilized
Alomone Labs is pleased to offer the TRPA1 Channel Modulator Explorer Kit (#EK-120). The Explorer Kit contains TRPA1 blockers and activators, ideal for screening purposes.
For research purposes only, not for human use
Compounds
Compounds
| Product Name | Cat # | Size |
|---|---|---|
A 967079 |
A-225 | 1 x 5 mg |
AP-18 |
A-250 | 1 x 5 mg |
Chembridge-5861528 |
C-235 | 1 x 5 mg |
Curcumin |
C-230 | 1 x 5 g |
5-(N,N-Dimethyl)amiloride hydrochloride |
D-165 | 1 x 5 mg |
HC-030031 |
H-105 | 1 x 10 mg |
Ligustilide |
L-170 | 1 x 10 mg |
4-ONE |
O-145 | 1 x 5 mg |
Ononetin |
O-135 | 1 x 50 mg |
Optovin |
O-140 | 1 x 5 mg |
ProTx-I |
STP-400 | 1 x 50 µg |
Scientific Background
Scientific Background
Scientific Background
The TRPA family is comprised of only one mammalian member, the TRPA1 (formerly named ANKTM1). TRPA1 is expressed in peripheral sensory neurons, where it is suggested to contribute to the detection of painful stimuli.1
Originally it was thought that TRPA channels sensed painfully cold temperatures2, but a more conservative description is that TRPA1 is sensitive to membrane/cytoskeletal perturbations by cold3-5 and perhaps stretch.6 In addition, it is sensitive to pungent natural compounds present in cinnamon oil, mustard oil, and wintergreen oil.
References
- Hill, K. and Schaefer, M. (2007) J. Biol. Chem. 282, 7145
- Zurborg, S. et al. (2007) Nat. Neurosci. 10, 277.
- Bandell, M. et al. (2004) Neuron 41, 849.
- Corey, D.P. et al. (2004) Nature 432, 723.
- Jordt, S.E. et al. (2004) Nature 427, 260.
- Story, G.M. et al. (2003) Cell 112, 819.
Related Products
Related Products
Related Products
- Anti-TRPA1 (extracellular) Antibody (#ACC-037)
- TRPA1 Channel Activator Explorer Kit (#EK-123)
- TRPA1 Channel Blocker Explorer Kit (#EK-121)
- Mechanosensitive TRP Channel Antibody Explorer Kit (#AK-305)
- TRP Channel Antibodies for Pain Research Explorer Kit (#AK-370)
- TRPA1 Channel Basic Research Pack (#ESB-302)
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