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Certificate of Analysis

  • Bioassay Tested

TRPM8 Channel Blocker Explorer Kit

A Screening Package of TRPM8 Channel Blockers Economically Priced

Cat #: EK-151
Size: 6 Vials
Form: Lyophilized

AMG-9090 Cat #: A-300

Size: 5 mg Source: Synthetic MW: 395.12 Purity: >98%
Effective concentration
50 nM - 50 µM.
Activity
AMG-9090 is TRPA1 channel blocker, shown to potently and concentration-dependently inhibit AITC-induced increase in intracellular calcium mediated by human TRPA1 (IC50 = 21 nM)1,2. The compound also possesses inhibitory effects on human TRPM8 and TRPV1 channels1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Protect from light.
Reconstitution
Up to 50 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.

AMTB hydrochloride Cat #: A-305

Size: 5 mg Source: Synthetic MW: 430.99 Purity: >97%
Effective concentration
1-100 µM.
Activity
AMTB hydrochloride is a TRPM8 channel blocker, inhibiting icilin-induced human TRPM8 channel activation (pIC50 = 6.23), selective over TRPV1 and TRPV41.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored desiccated at -20°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.

AMG2850 Cat #: A-340

Size: 5 mg Source: Synthetic MW: 417.35 Purity: >99% (HPLC)
Effective concentration
0.1-10 µM.
Activity
AMG2850 is a potent and selective blocker of TRPM8 channels. It was shown in vitro to inhibit rat TRPM8 cold, menthol and icilin activation with IC50 of 7.3 nM, 156 nM and 204 nM, respectively. Highly selective for TRPM8 over TRPV1 and TRPA1 channels and orally bioavailable (Fpo>40%)1,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Up to 200 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.

M8-B hydrochloride Cat #: M-220

Size: 5 mg Source: Synthetic MW: 432.96 Purity: >99%
Effective concentration
10 nM - 10 µM.
Activity
M8-B hydrochloride is a potent and selective blocker of TRPM8 channel, inhibiting rat and human TRPM8 activation by cold, by icilin and by menthol with IC50 values of 7.8 nM, 26.9 nM and 64.3 nM, respectively, whilst having little or no effect on other TRP channels (IC50 > 20 μM)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored desiccated at +4°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.

RQ 00203078 Cat #: R-170

Size: 5 mg Source: Synthetic MW: 554.84 Purity: >99%
Effective concentration
1 nM – 1 µM.
Activity
RQ 00203078 is a potent and selective TRPM8 antagonist, shown to inhibit menthol-evoked human and rat TRPM8-mediated calcium influx with IC50 of 8.3 nM and 5.8 nM, respectively, while being highly selective over hTRPV4, h/rTRPV1, h/rTRPA1 and TRPM21,2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at +4°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.

TC-I 2014 Cat #: T-200

Size: 5 mg Source: Synthetic MW: 467.41 Purity: >96%
Effective concentration
1 nM – 1 µM.
Activity
TC-I 2014 is a potent and selective TRPM8 blocker, inhibiting canine, rat, and human TRPM8-mediated Ca2+ influx with IC50 values of 0.8, 4.0, and 3.0 nM, respectively1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at +4°C.
Reconstitution
Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Storage after reconstitution
Up to three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.

For research purposes only, not for human use
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