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Certificate of Analysis

  • Bioassay Tested

TRPV1 Channel Modulator Explorer Kit

A Screening Package of TRPV1 Channel Modulators Economically Priced

Cat #: EK-114
Size: 14 Vials
Form: Lyophilized

A 784168 Cat #: A-345

Size: 5 mg Source: Synthetic MW: 479.4 Purity: >99%
Effective concentration
10 nM - 1 µM.
Activity
A 784168 is a potent TRPV1 antagonist, inhibiting human TRPV1 activation by 50 nM capsaicin with IC50 of 25 nM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO or 50 mM in ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

A-889425 Cat #: A-195

Size: 1 mg Source: Synthetic MW: 425.4 Purity: >98% (HPLC)
Effective concentration
0.5 nM - 50 µM.
Activity
A-889425 blocks TRPV1 channels with an IC50 of 335 nM (rat) and 34 nM (human)1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO up to 100 mM. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

AM 404 Cat #: A-190

Size: 5 mg Source: Synthetic MW: 395.6 Purity: >98% (HPLC)
Effective concentration
0.5 nM - 50 µM.
Activity
AM 404 activates TRPV1 channels with EC50 = 0.04 µM1, and serves as a ligand for CB1 cannabinoid receptors2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO, 50 mM in ethanol (dissolves slowly). Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Arvanil Cat #: A-335

Size: 10 mg Source: Synthetic MW: 439.64 Purity: >96% (HPLC)
Effective concentration
1 nM – 1 µM.
Activity
Arvanil is an agonist of TRPV1 channels (EC50 = 0.5 nM), a ligand of CB1 receptors (Ki = 0.25-0.5 μM), and an inhibitor of anandamide accumulation (IC50 = 3.6 µM). In vivo it demonstrates vasodilator, analgesic, and anti-inflammatory properties. Arvanil inhibits human breast cancer cell proliferation and the growth of astrocytoma xenograft tumors in mice1-3.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored desiccated at -20°C.
Reconstitution
Soluble in ethanol and DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

BCTC Cat #: B-110

Size: 10 mg Source: Synthetic MW: 372.9 Purity: >99% (HPLC)
Effective concentration
1 nM – 100 nM.
Activity
BCTC is a potent and selective antagonist of TRPV1 channels, shown to inhibit capsaicin-, pH- and PKC-induced responses of mouse TRPV1 with IC50 of 1.3, 0.59 and 0.37 nM, respectively.1,2 BCTC is also a blocker of TRPM8 channels, inhibiting rat TRPM8-mediated menthol and cold-evoked Ca2+ response with IC50 of 0.6 µM.3
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
1-10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Capsaicin Cat #: C-125

Size: 50 mg Source: Natural (from Capsicum sp.) MW: 305.4 Purity: >98% (HPLC)
Effective concentration
0.1-10 μM.
Activity
Capsaicin is one of the most powerful chemical agonists of the TRPV1 (transient receptor potential vanilloid) channel. It is a small lipophilic molecule derived from hot chili peppers that acts on sensory neurons by opening TRPV1, a principal transduction channel for nociception1. Capsaicin acts directly on TRPV12, with half-maximal effective concentration of 711.9 nM in Xenopus oocytes3 and 0.29 μM in HEK293 cells4.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to one week at 4°C or six months at -20°C.

Capsazepine Cat #: C-120

Size: 5 mg Source: Synthetic MW: 376.9 Purity: >97%
Effective concentration
0.1-100 µM.
Activity
Capsazepine is a selective antagonist of the vanilloid VR1 receptor (TRPV1) with IC50 of 40 nM, and an activator of the ENaC channels.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

LASSBio-1135 Cat #: L-190

Size: 5 mg Source: Synthetic MW: 286.3 Purity: >99%
Effective concentration
0.1-100 µM.
Activity
LASSBio-1135 is a TRPV1 channel and a TNF-α receptor antagonist1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Nonivamide Cat #: N-220

Size: 250 mg Source: Synthetic MW: 293.4 Purity: >98%
Effective concentration
100 nM - 10 µM.
Activity
Nonivamide is a TRPV1 activator1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

OLDA Cat #: O-120

Size: 5 mg Source: Synthetic MW: 417.6 Purity: >96%
Effective concentration
0.5 nM – 50 µM.
Activity
OLDA activates TRPV1 channels with an EC50 ~ 0.36 µM1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Ethanol and DMSO up to 50 mM. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Olvanil Cat #: O-115

Size: 5 mg Source: Synthetic MW: 417.6 Purity: >99%
Effective concentration
0.5 nM - 50 µM.
Activity
Olvanil is an opener of TRPV1 channels (EC50 ~ 0.001 µM)1 and an activator of Cannabinoid receptors2.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Ethanol (up to 20.9 mg/ml). Centrifuge all product preparations before use (10000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

Palvanil Cat #: P-205

Size: 5 mg Source: Synthetic MW: 391.3 Purity: 100%
Effective concentration
5 nM - 5 µM.
Activity
Palvanil activates TRPV1 channels at 100 nM in a slower manner than capsaicin1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO 10 mM. Centrifuge all product preparations before use (10000 x g for 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

SB-366791 Cat #: S-180

Size: 10 mg Source: Synthetic MW: 287.7 Purity: >99%
Effective concentration
5 nM - 50 µM.
Activity
SB-366791 is a TRPV1 channel antagonist1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

SB-705498 Cat #: S-160

Size: 5 mg Source: Synthetic MW: 428.05 Purity: >99%
Effective concentration
10 nM - 50 µM.
Activity
SB-705498 is a potent orally active TRPV1 blocker1.
Storage before reconstitution
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
DMSO 100 mM. Centrifuge all product preparations before use (10000 x g 1 min).
Storage after reconstitution
Up to four weeks at 4°C or three months at -20°C.

For more information, please refer to individual certificate of analysis for each product.

For research purposes only, not for human use
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