- Alomone Labs TTA-P2 (S-enantiomer) blocks T-type CaV channels expressed in Xenopus oocytes.A. Time course of CaV3.2 peak current amplitude, elicited by 100 ms voltage step from holding potential of -100 mV to -30 mV, delivered every 10 seconds. Application of 5 µM TTA-P2 (S-enantiomer) (#T-210) inhibits the CaV3.2 current in a reversible manner (indicated by the horizontal bar). B. Representative current traces before and during application of 5 µM TTA-P2 as indicated.
TTA-P2 is a novel, potent and selective T-type CaV channel blocker. In thalamocortical and reticular neurons, it blocks T-type currents with an IC50 of 22 nM without affecting high voltage Ca2+ channels1. In rat DRGs, it blocks T-type currents with an IC50 of 100 nM and stabilizes the channel in the inactive state2.
TTA-P2 has the potential of acting as an antinociceptive agent2.
TTA-P2 (S-enantiomer) (#T-210) is a highly pure, synthetic, and biologically active compound.