Cat #: V-110
This product is freeze dried. All water molecules have been removed.
Every lot is tried & tested in a relevant biological assay.
Origin Veratrum officinale.
Effective concentration 1-200 μM.
Chemical name 4α,9-Epoxy-3β-veratroyloxy-5β-cevan-4β,12,14,16β,17,20-hexaol.
Molecular formula C36H51NO11.
CAS No.: 71-62-5.
Activity Veratridine is an alkaloid which is a potent modulator of voltage-dependent Na+ channels and hence, of transmitter release1,2. Veratridine reduces the single channel conductance and increases the persistent opening propability3.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C.
Alomone Labs Veratridine modulates NaV1.4 Na+ currents in Xenopus oocytes.A. Superimposed example current traces of NaV1.4 channels before (black) and during application of 100 μM Veratridine (#V-110), (green). Note that the current is inhibited during the peak, but is enhanced at its end and especially once the membrane potential is back to rest (tail). B. Time course of NaV1.4 channel activity (measured at the tail current) before and during applications of 100 μM Veratridine (green) and upon wash. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to 0 mV.
Veratridine is an alkaloid extracted from the Veratrum officinale plant, which is a potent modulator of voltage dependent Na+ channels and hence, of transmitter release1,2. Veratridine reduces the single channel conductance and increases the persistent opening probability of NaV1.4 channels expressed in a mammalian cell line3. Veratridine affects differentially the TTX-sensitive and TTX-resistant components of NaV currents in rat DRG neurons. Although veratridine inhibits both components at the peak current, it is much more effective in increasing the persistent component (channel opening) of the TTX sensitive currents4. Veratridine is widely used in different excitable preparations to induce NaV channel dependent transmitter release (see for example reference #5).
Target Various NaV Na+ channels
Last update: 03/03/2019
Veratridine (#V-110) is a highly pure, natural, and biologically active compound.
For research purposes only, not for human use