Overview
Cat #:
Size:
10 mg
Lot:
Z140SM0110
Alternative Name Sonata®, Zerene, CL-284846, Zalaplon
Lyophilized Powder yes
Source Synthetic
MW: 305.34
Purity: >98%.
Effective concentration 10 nM – 10 µM.
Structure
Chemical name N-[3-(Cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide.
Molecular formula C17H15N5O.
CAS No.: 151319-34-5
PubChem CID 5719
Activity A non-benzodiazepine pyrazolopyrimidine agonist at the benzodiazepine site of the GABAA receptors. Potentiates GABA-induced chloride currents at sub-micromolar concentrations1. Displaces [3H]Flunitrazepam from rat cerebellum and spinal cord membranes with IC50 values of 167 nM and 2.38 µM, respectively2.
References-Activity
- Sanna, E. et al. (2003) J. Neurosci. 23, 11711.
- Noguchi, H. et al. (2002) Eur. J. Pharmacol. 434, 21.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored desiccated at 4°C.
Protect from light.
Protect from light.
Solubility Up to 100 mM in DMSO. Centrifuge all products before reconstitution (10000 x g 5 min).
Storage of solutions Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted product for storage.
Our bioassay
- Alomone Labs Zaleplon inhibits specific binding of Flunitrazepam to rat brain GABA(A) receptors.Percent inhibition of specific binding of 1 nM [3H]Flunitrazepam to membranes from whole rat brain (except cerebellum) was plotted against concentrations of Zaleplon (#Z-140), (green circles) and of Diazepam (assay standard, black squares) and used to calculate IC50 and Ki values for Zaleplon (IC50 ≈ 0.55 μM, and Ki ≈ 0.45 μM).
Target GABA(A) receptors
Lyophilized Powder
For research purposes only, not for human use
Last Update: 24/12/2020
Specifications
Citations
Citations