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Metabotropic Glutamate Receptors


Metabotropic glutamate receptors (mGluRs) belong to the super family of G-protein coupled receptors (seven transmembrane proteins). mGluRs are further divided into subfamilies: group I mGluRs (mGluR1 and mGluR5) which couple to Gq, thereby activating phospholipase C (PLC). Group II which include mGluR2 and mGluR3 couple to Gi, therefore inhibit the formation of adenylate cyclase. mGluR4, 6, 7, 8 which belong to group III also inhibit adenylate cyclase formation by coupling to Gi.

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  • L-AP4

    A Potent and Selective Agonist of Group III mGluRs

    Cat # L-150
    Source Synthetic
    MW 183.1
    Target mGluR4, 6, 7, 8
    • Bioassay Tested

* See product page

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