Antagonists

Endothelin Receptors

Antagonists

Endothelin, a 21–amino acid peptide, has potent and sustained vasoconstrictive effects on vascular smooth muscle both in vivo and in vitro and is found in three different isoforms. ET-1 binds and activates two G-protein coupled receptors: ET-A and ET-B. While the former has been attributed to vasoconstriction, the role of ET-B depends mostly on its location; on one hand it could promote vasoconstriction and on the other stimulate nitric oxide (NO) release -a known vasodilator.

Displaying 1 to 20 (out of 24 products)
  • A-192621

    A Selective Antagonist of Endothelin B Receptors

    Cat # A-360
    Source Synthetic
    MW 558.68
    Target ET-B receptor
  • ACT-132577

    An Antagonist of Endothelin Receptors

    Cat # A-350
    Source Synthetic
    MW 546.19
    Target Endothelin receptors
  • Atrasentan

    A Potent and Selective Antagonist of Endothelin A Receptors

    Cat # A-455
    Source Synthetic
    MW 510.62
    Target ET-A receptors
  • Avosentan

    A Selective Antagonist of Endothelin A Receptors

    Cat # A-355
    Source Synthetic
    MW 479.51
    Target ET-A receptors
  • BMS 182874 hydrochloride

    A Selective Antagonist of Endothelin A Receptors

    Cat # B-500
    Source Synthetic
    MW 381.88
    Target ET-A receptors
  • Bosentan hydrate

    An Antagonist of Endothelin Receptors

    Cat # B-170
    Source Synthetic
    MW 569.63
    Target Endothelin receptors
  • BQ-123 sodium salt

    A Selective Antagonist of Endothelin A Receptors

    Cat # B-185
    Source Synthetic
    MW 632.69
    Target ET-A receptors
  • BQ-123 trifluoroacetate

    A Selective Antagonist of Endothelin A Receptors

    Cat # B-186
    Source Synthetic
    MW 724.74
    Target ET-A receptors
  • BQ788

    A Selective Antagonist of Endothelin B Receptors

    Cat # B-175
    Source Synthetic
    MW 641.81
    Target ET-B receptor
  • BQ788 sodium salt

    A Selective Antagonist of Endothelin B Receptors

    Cat # B-176
    Source Synthetic
    MW 663.79
    Target ET-B receptor
  • Darusentan

    A Selective Antagonist of Endothelin A Receptors

    Cat # D-265
    Source Synthetic
    MW 410.43
    Target ET-A receptors
  • FR 139317

    A Selective Antagonist of Endothelin A Receptors

    Cat # F-180
    Source Synthetic
    MW 604.75
    Target ET-A receptors
  • IRL 2500

    An Antagonist of Endothelin B Receptors

    Cat # I-190
    Source Synthetic
    MW 573.69
    Target ET-B receptor
  • PD-156707

    A Potent and Selective Antagonist of Endothelin A Receptors

    Cat # P-305
    Source Synthetic
    MW 528.49
    Target ET-A receptor
  • PD-164333

    A Selective Antagonist of Endothelin A Receptors

    Cat # P-310
    Source Synthetic
    MW 823.63
    Target ET-A receptors
  • Ro46-8443

    A Selective Antagonist of Endothelin B Receptors

    Cat # R-185
    Source Synthetic
    MW 609.69
    Target ET-B receptor
  • SB209670

    A Potent Antagonist of Endothelin Receptors

    Cat # S-205
    Source Synthetic
    MW 520.53
    Target Endothelin receptors
  • Sitaxsentan

    A Potent and Selective Antagonist of Endothelin A Receptor

    Cat # S-186
    Source Synthetic
    MW 454.9
    Target ET-A receptors
  • Sitaxsentan sodium salt

    A Potent and Selective Antagonist of Endothelin A Receptor

    Cat # S-185
    Source Synthetic
    MW 476.88
    Target ET-A receptors
  • TAK-044

    A Non-Selective Antagonist of Endothelin Receptors

    Cat # SPE-320
    Source Synthetic
    MW 927 Da.
    Target Endothelin receptors

* See product page

Displaying 1 to 20 (out of 24 products)