Antagonists

Kainate Receptors

Antagonists

The kainate receptor subfamily consists of five members that have been further subdivided into two classes based upon structural homology and functional characteristics. GluR5, GluR6, and GluR7 receptor subunits share a high degree of homology and are able to form functional channels when expressed in heterologous systems. The KA-1 and KA-2 receptors are unable to form functional channels on their own, but when coexpressed with GluR5-7 receptor subunits, they form channels with high affinity for kainate. Like AMPA receptors, the functional unit of endogenous kainate receptors is believed to be a tetramer, which can be either homomeric or heteromeric. Kainate receptors GluR5 and GluR6 (but not GluR7, KA-1, or KA-2) can undergo RNA editing; as in the AMPA receptor GluR2, a glutamine (Q) residue in the channel pore is edited to encode arginine (R) in the mature protein. Substitution of Q with R modulates the properties of the channel, producing channels with reduced single channel conductance and lower permeability to Ca2+.

Displaying 1 to 14 products (out of 14 products)
  • (S)-ATPO

    An Antagonist of AMPA/Kainate Receptors

    Cat # A-330
    Source Synthetic
    MW 322.25
    Target AMPA/Kainate receptors
  • CNQX

    AMPA/Kainate Receptor Antagonist

    Cat # C-140
    Source Synthetic
    MW 232.2
    Target AMPA/Kainate receptors
  • CNQX disodium salt

    AMPA/Kainate Receptor Antagonist

    Cat # C-141
    Source Synthetic
    MW 276.1
    Target AMPA/Kainate receptors
  • DNQX

    AMPA/Kainate Receptor Antagonist

    Cat # D-131
    Source Synthetic
    MW 252.1
    Target AMPA, Kainate receptors
  • DNQX disodium salt

    AMPA/Kainate Receptor Antagonist

    Cat # D-130
    Source Synthetic
    MW 296.1
    Target AMPA/Kainate receptors
  • Evans Blue tetrasodium salt

    An Antagonist of AMPA/Kainate receptors, P2X Receptors and a Potent Inhibitor of L-Glutamate Uptake

    Cat # E-110
    Source Synthetic
    MW 960.8
    Target AMPA, Kainate, P2X receptors
  • GYKI 52466 hydrochloride

    An Antagonist of AMPA and Kainate Receptors

    Cat # G-125
    Source Synthetic
    MW 293
    Target AMPA/Kainate receptors
  • GYKI 53655 hydrochloride

    An Antagonist of AMPA and Kainate Receptors

    Cat # G-220
    Source Synthetic
    MW 388.85
    Target AMPA, Kainate receptors
  • Kynurenic acid

    An Antagonist of Ionotropic Glutamate Receptors and α7 nAChR

    Cat # K-110
    Source Synthetic
    MW 189.2
    Target iGluR, α7 nAChR
  • NBQX

    An Antagonist of AMPA/Kainate Receptors

    Cat # N-185
    Source Synthetic
    MW 336.3
    Target AMPA/Kainate receptors
  • NBQX disodium salt

    An Antagonist of AMPA/Kainate Receptors

    Cat # N-186
    Source Synthetic
    MW 380.2
    Target AMPA/Kainate receptors
  • Talampanel

    A Potent Non-Competitive Antagonist of AMPA/Kainate Receptors

    Cat # T-185
    Source Synthetic
    MW 337.37
    Target AMPA/Kainate receptors
  • UBP 282

    An Antagonist of AMPA and Kainate Receptors

    Cat # U-110
    Source Synthetic
    MW 333.29
    Target AMPA, Kainate receptors
  • Classical Ion Channel Blockers for Pain Research Explorer Kit

    A Screening Package of Classical Ion Channel Blockers for Pain Research Economically Priced

    Cat # EK-355
    • Lyophilized Powder
    • Bioassay Tested
    • Shipped at Room Temp.
    • 100% Net Peptide

* See product page

Displaying 1 to 14 products (out of 14 products)