Antagonists

Orexin Receptors

Antagonists

Both OX1R and OX2R belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. OX2R is thought to transmit signals through the Ga11 class of G proteins, resulting in the activation of phospholipase C with subsequent triggering of the phosphatidylinositol cascade and an influx of extracellular Ca2+, probably through transient receptor potential (TRP) channels.

Displaying 1 to 2 products (out of 2 products)
  • ACT-462206

    A Potent Antagonist of Orexin1/2 Receptors

    Cat # A-450
    Source Synthetic
    MW 388.48
    Target OX1, OX2 orexin receptors
    • Bioassay Tested
  • Lemborexant

    A Potent Antagonist of Orexin1/2 Receptors

    Cat # L-255
    Source Synthetic
    MW 410.43
    Target OX1, OX2 orexin receptors
    • Bioassay Tested

* See product page

Displaying 1 to 2 products (out of 2 products)