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Leucine-Rich Repeat Kinase (LRRK) Family


ROCO is a family of multidomain proteins characterized by the presence of tandem ROC (Ras of Complex Proteins) and COR (C-terminal of ROC) domains. In humans, ROCO proteins comprises four members- Leucine-rich repeat kinase 1 (LRRK1), Leucine-rich repeat kinase 2 (LRRK2), death-associated kinase 1 (DAPK1) and Malignant fibrous histiocytoma amplified sequence 1 (MFASH1). In addition, LRRK1 contains GTPase domain and MAPKKK-like kinase domain. LRRK1 structure includes a serine-threonine kinase domain C-terminal of ROC-COR, and leucine-rich and ankyrin-like repeats at the N-terminus.

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