NOW you can conduct flow cytometry using live cells in ONE single step.
These novel antibodies save you valuable time and resources, while empowering your research results.
✓ Developed for flow cytometry (FACS) ✓ Tested with appropriate isotype control ✓ No need for secondary antibodies ✓ Conjugated to “extracellular” antibodies ✓ Cell-surface detection of proteins ✓ Permeabilization & cell fixation not required ✓ Time saving
Within our antibody portfolio, we gladly take on special requests for customized antibody labeling/conjugation.
The melanocortin signaling system plays a role in many physiological outcomes such as skin pigmentation, food intake, sexual behavior and more. Melanocortin receptors (MCRs) 1 through 5, belong to the superfamily of G-protein coupled receptors, and mediate the effects of five different peptides: ACTH, α-MSH, β-MSH and γ-MSH. In addition, this system has endogenous antagonists: agouti and AGRP. Agouti inhibits MCR1 and MCR4, while AGRP antagonizes MCR3 and MCR4. These two antagonists, when overexpressed in mice, give rise to obese animals, and in some cases, obese and diabetic subjects.