NOW you can conduct flow cytometry using live cells in ONE single step.
These novel antibodies save you valuable time and resources, while empowering your research results.
✓ Developed for flow cytometry (FACS) ✓ Tested with appropriate isotype control ✓ No need for secondary antibodies ✓ Conjugated to “extracellular” antibodies ✓ Cell-surface detection of proteins ✓ Permeabilization & cell fixation not required ✓ Time saving
Within our antibody portfolio, we gladly take on special requests for customized antibody labeling/conjugation.
Sphingosine 1-phosphate (S1P) is an active byproduct of sphingomyelin metabolism. Upon secretion, it circulates in the blood via its binding to high-density lipoproteins and albumin. When S1P reaches its target cell it could activate 5 different high affinity receptors belonging to the G-protein coupled receptor superfamily: Sphingosine 1-phosphate receptors, termed S1PR1-5. Stimulation of S1PR receptors triggers a cascade of signaling events depending on the receptor and on the G-protein it couples. Through the different signaling pathways these receptors activate, S1PR receptors are implicated in adherens junction assembly, cytoskeletal changes, cell migration, proliferation and apoptosis.