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Antibodies to Pannexins

Purinergic (P2Y) Receptors

Antibodies to Pannexins

Hypoxia or inflammation, activates the release of extracellular nucleotides such as ATP and UTP which interact with cell surface P2Y receptors to produce a broad range of physiological responses including cardiac function, platelet aggregation and smooth muscle cell proliferation. Eight mammalian P2Y receptors, members of G-protein coupled receptors, have been identified on the basis of sequence homology and pharmacological profile: the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14.

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