Antibodies to Ryanodine Receptors

Ryanodine Receptor Channels

Antibodies to Ryanodine Receptors

Ryanodine Receptors (RyRs), named so due to their direct modulation by the plant alkaloid ryanodine, are the large conductance Ca2+ channel in the endoplasmic reticulum (ER) membrane of excitable cells such as muscles and neurons. There are three isoforms which form homotetramers: RyR1 expressed mainly in skeletal muscle; RyR2 is particular to myocardium and RyR3 is mostly expressed in the brain.

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