Guinea Pig-Raised Antibodies: Antibodies raised in guinea pig can be used with any non-guinea pig second species antibodies (e.g. antibodies raised in mouse, rabbit, goat, etc.) in complex immunostaining or immunoprecipitation protocols. Our line of guinea pig raised antibodies can be combined with any of our rabbit-raised or ATTO-conjugated antibodies in complex immunostaining protocols.
Neurotrophins, like many growth factors, are expressed as precursor proteins which are then truncated and further modified to yield the mature form. The presence of highly conserved sequences in the prodomains of different neurotrophins made it clear that the prodomain must have some biological role and is not solely present as a protein folding chaperone. Proneurotrophins mediate their signaling by binding to p75NTR and Sortilin receptors.