Biotinylated Toxins

Voltage-Gated Ca2+ Channels

Biotinylated Toxins

Voltage-dependent Ca2+ channels (CaV) form an important route for Ca2+ entry into cells, upon deviations from the cells’ resting membrane potential. There are ten CaV α1 subunit genes, divided into three subfamilies on both a functional and sequence homology basis. The CaV1 subfamily includes four genes which encode the L-type channels, the CaV3 subfamily includes three genes encoding the T-type channels and the CaV2 subfamily consists of three isoforms encoding P/Q- , N- and R-type channels, with all three contributing to neurotransmitter release in neurons.

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  • ProTx-II-Biotin

    A Blocker of NaV1.7 and NaV1.5 Channels and some T-Type Ca2+ Channels Conjugated to Biotin

    Cat # STP-100-B
    Source Synthetic
    MW 4053 Da.
    Target NaV Na+ channels and T-type Ca2+ channels

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