Blockers

Epithelial Na+ Channels (ENaC)

Blockers

ENaC channels are composed of three structurally related subunits: α, β, and γ which mostly coassemble as heteromeric structures in order to form functional channels. Structurally, channels belonging to the ENaC/ Degenerin superfamily have short N- and C-termini and a large extracellular loop. In addition, strong evidence suggests that furin proteases cleave their extracellular loop for full channel activation. These channels are highly sensitive to amiloride and are hence commonly termed amiloride-sensitive channels.

Displaying 1 to 4 products (out of 4 products)
  • Amiloride hydrochloride

    Blocker of ENaC/ASIC/Degenerin Channels

    Cat # A-140
    Source Synthetic
    MW 266.09
    Target ENaC, ASIC, TRPP3 channels, NHE-1 transporter
  • Benzamil

    An Inhibitor of Na+/Ca2+ Exchangers and a Blocker of ASIC, TRPP3 and TRPA1 Channels

    Cat # B-161
    Source Synthetic
    MW 319.75
    Target Na+/Ca2+ exchangers, ASIC/ENaC, TRPP3, TRPA1 channels
  • Benzamil hydrochloride

    An Inhibitor of Na+/Ca2+ Exchangers and a Blocker of ASIC, TRPP3 and TRPA1 Channels

    Cat # B-160
    Source Synthetic
    MW 356.21
    Target Na+/Ca2+ exchangers, ASIC/ENaC, TRPP3, TRPA1 channels
  • Capsazepine

    A Selective TRPV1 Blocker and an Activator of ENaCγ Channels

    Cat # C-120
    Source Synthetic
    MW 376.9
    Target TRPV1, ENaCγ channels

* See product page

Displaying 1 to 4 products (out of 4 products)