Blockers

Hyperpolarization-Activated Cation (HCN) Channels

Blockers

Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels comprise a small subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the HCN channel family comprises four members (HCN1-4) that are expressed in the heart and in the nervous system. Hyperpolarization-activated cation currents produced by HCN channels (Ih, If or Iq), contribute to a wide range of physiological functions including cardiac and neuronal pacemaker activity, the setting of resting potentials, dendritic integration of synaptic transmission and learning.

Displaying 1 to 3 products (out of 3 products)
  • Lidocaine

    A State-Dependent NaV Channel Inhibitor

    Cat # L-105
    Source Synthetic
    MW 234.3
    Target NaV, HCN channels
  • Lidocaine hydrochloride

    A State-Dependent Blocker of Neuronal NaV Channels

    Cat # L-145
    Source Synthetic
    MW 270.8
    Target NaV, HCN channels
  • Loperamide hydrochloride

    An Antagonist of L-type and T-type CaV Channels, HCN Channels, NMDA Receptors and an Agonist of μ-Opioid Receptors

    Cat # L-100
    Source Synthetic
    MW 513.5
    Target L-type, T-type Ca2+, HCN channels, NMDA, μ-opioid receptors

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Displaying 1 to 3 products (out of 3 products)