Extracellular antibodies are ideal research tools for cell-surface proteins.
No permeabilization/fixation because using extracellular antibodies allows you to work with live cells!
Benefits of live cell imaging:
✓ Monitor cell movement
✓ Study protein transport across the cell
✓ Investigate protein internalization
P2X7 receptor is expressed in the immune system, particularly antigen presenting cells, and microglia. It mediates the release of proinflammatory cytokines, stimulation of transcription factors and may also play an important role in apoptosis.