Intracellular Ca<sup>2+</sup> Modulators

Calcium Homeostasis Modulators

Intracellular Ca2+ Modulators

Calcium homeostasis has major roles in different extra and intra cellular processes and is therefore crucial for cell physiology. CALHM channel gating is regulated allosterically by both voltage and Ca2+ concentration. Low concentrations of Ca2+ and depolarization cause channel activation. The molecular basis for voltage-dependent gating remains unknown. CALHM3 channels do not have canonical voltage sensors as found in other channels. CALHM channels poorly discriminate cations and anions enabling signaling molecules such as Ca2+ and ATP to permeate to its pore. This suggests a non-discriminatory ion selectivity filter or a wide ion conduction pore. Recent studies have shown that it is the latter and not the former that accounts for weak ion selectivity.

Displaying 1 to 11 products (out of 11 products)
  • A23187

    Widely Used Ca2+ Ionophore

    Cat # A-600
    Source Natural
    MW 523.6
  • Anhydroryanodine

    A Non Active Analogue of Ryanodine

    Cat # A-510
    Source Natural
    MW 475.54
  • Cyclopiazonic Acid

    A Potent Inhibitor of Intracellular Ca2+-ATPase Pump

    Cat # C-750
    Source Natural
    MW 336.4
    Target SERCA pump
  • Imperatoxin A

    A Ryanodine Receptor Modulator

    Cat # STI-333
    MW 3758 Da.
    Target Ryanodine receptors
  • Maurocalcine

    A Ryanodine Receptor 1, 2 & 3 Modulator

    Cat # RTM-100
    MW 3864 Da.
    Target Ryanodine receptors
  • Ochratoxin A

    A Potent Modulator of Ca2+ ATPase Pump

    Cat # O-400
    Source Natural
    MW 403.8
    Target SERCA pump
  • Paxilline

    A Mycotoxin Blocker of KCa1.1 (BK) Channels and SERCA Pumps

    Cat # P-450
    Source Natural
    MW 435.6
    Target KCa K+ channels, SERCA pump
  • Ryanodine

    A Blocker of Ryanodine Receptors

    Cat # R-500
    Source Natural
    MW 493.5
    Target Ryanodine receptors
  • tBuBHQ

    A Potent Inhibitor of Sarcolasmic Reticulum Ca2+ ATPase

    Cat # T-220
    Source Synthetic
    MW 222.33
    Target SERCA
  • Thapsigargin

    A Potent and Cell-Permeable Inhibitor of SERCA Pump Ca2+-ATPase/an Intracellular Ca2+ Mobilizer

    Cat # T-650
    Source Natural
    MW 650.7
    Target SERCA
  • Thapsigargin Epoxide

    A Nonactive Analogue of Thapsigargin

    Cat # T-670
    Source Natural
    MW 632.75
    Target SERCA

* See product page

Displaying 1 to 11 products (out of 11 products)