Modulators

Ryanodine Receptor Channels

Modulators

Ryanodine Receptors (RyRs), named so due to their direct modulation by the plant alkaloid ryanodine, are the large conductance Ca2+ channel in the endoplasmic reticulum (ER) membrane of excitable cells such as muscles and neurons. There are three isoforms which form homotetramers: RyR1 expressed mainly in skeletal muscle; RyR2 is particular to myocardium and RyR3 is mostly expressed in the brain.

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