Antagonists

Glutamate Transporters

Antagonists

The transport of Glu into the cells by the EAAT transporters is coupled to the Na+ and K+ electrochemical gradient as a driving force. Hence, the uptake of Glu is dependent on the co-transport of three Na+ and one H+ ions, and the counter transport of one K+ ion.
In addition, to the well documented Glu uptake, the EAAT transporters show a Glu-independent Cl conductance. The physiological significance of the Cl current through the EAATs is currently unknown.

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  • Evans Blue tetrasodium salt

    An Antagonist of AMPA/Kainate receptors, P2X Receptors and a Potent Inhibitor of L-Glutamate Uptake

    Cat # E-110
    Source Synthetic
    MW 960.8
    Target AMPA, Kainate, P2X receptors

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