Inhibitors

Protein Kinases

Inhibitors

Protein Kinases (PK) comprise a large family of enzymes that mediate the transfer of a phosphate group from a donor molecule (usually ATP) to hydroxyamino acids. The enzymes fall into two broad classes, characterized with respect to substrate specificity: serine/threonine specific and tyrosine specific. Protein kinases play an essential role in many signaling pathways, and therefore have the potential to contribute to diseases ranging from cancer and inflammation to diabetes and cardiovascular disorders, not to mention cell growth, survival and many other biological functions. Most PK inhibitors act by competing with ATP for binding to the kinase. This is possible because of structural similarities between ATP and the inhibitors.

Displaying 1 to 20 (out of 22 products)
  • ANA-12

    A Selective Antagonist of TrkB Receptor

    Cat # A-215
    Source Synthetic
    MW 407.49
    Target TrkB receptor
  • Chelerythrine chloride

    An Inhibitor of Protein Kinase C, SERCA Pump, and P2X7 Receptor

    Cat # C-400
    Source Natural
    MW 383.84
    Target PKC, SERCA pumps, P2X7 receptor
  • Genistein

    A Tyrosine Kinase Inhibitor

    Cat # G-300
    Source Natural
    MW 270.2
  • HA-1077

    A Rho/Rok Inhibitor

    Cat # H-220
    Source Synthetic
    MW 364.3
  • K252a

    A Potent Inhibitor of Protein Kinase A, Protein Kinase C, and Protein Kinase G

    Cat # K-150
    Source Natural
    MW 467.5
  • K252b

    A Potent Inhibitor of Protein Kinase A, Protein Kinase C, and Protein Kinase G

    Cat # K-170
    Source Natural
    MW 453
  • KT5720

    A Selective PKA Inhibitor

    Cat # K-190
    Source Semi-synthetic
    MW 537
  • KT5823

    A Selective PKG Inhibitor

    Cat # K-250
    Source Semi-synthetic
    MW 495
  • LY 294002

    A Specific Inhibitor of PI3-Kinase

    Cat # L-300
    Source Synthetic
    MW 307.35
  • Olomoucine

    A Cyclin-Dependent Kinase (CDK) Inhibitor

    Cat # O-300
    Source Synthetic
    MW 298.35
  • Parthenolide

    A Nuclear Factor-κB (NF-κB) Pathway Inhibitor

    Cat # P-250
    Source Natural
    MW 248.3
  • PD 98059

    A Potent Inhibitor of Mitogen-Activated Protein Kinase (MAPK) Pathway

    Cat # P-260
    Source Synthetic
    MW 267.28
  • PD 153035

    A Potent EGF Receptor Tyrosine Kinase Inhibitor

    Cat # P-360
    Source Synthetic
    MW 360.21
  • Radicicol

    An Anticancer Antibiotic

    Cat # R-370
    Source Natural
    MW 364.78
  • Roscovitine

    A Cyclin-Dependent Kinase (CDK) Inhibitor and a T-Type CaV Channel Blocker

    Cat # R-300
    Source Synthetic
    MW 354.46
    Target CDKs, T-type CaV channels
  • SB 203580

    A MAPK Homologue-p38 Inhibitor

    Cat # S-370
    Source Synthetic
    MW 377.44
  • Staurosporine

    A Potent Inhibitor of Protein Kinase A, Protein Kinase C, and Protein Kinase G

    Cat # S-350
    Source Natural
    MW 466
  • Tyrphostin AG 490

    A JAK Inhibitor

    Cat # T-700
    Source Synthetic
    MW 294.31
  • Tyrphostin AG 1296

    A PDGF Receptor Tyrosine Kinase Inhibitor

    Cat # T-770
    Source Synthetic
    MW 266.3
  • Tyrphostin AG 1478

    A Potent EGF Receptor Tyrosine Kinase Inhibitor

    Cat # T-320
    Source Synthetic
    MW 315.76

* See product page

Displaying 1 to 20 (out of 22 products)