Microglia Markers

Microglia Markers

Microglia are the resident immune cells of the central nervous system (CNS). They originate from yolk sac progenitors during embryonic development and serve as the brain’s primary innate immune defense. In the healthy CNS, microglia continuously survey the microenvironment, contributing to synaptic pruning, neurogenesis, and tissue homeostasis. Upon injury, infection, or neurodegeneration, they become activated and undergo morphological and functional changes, including cytokine release, phagocytosis, and antigen presentation.

To support microglia research, Alomone Labs offers a wide range of high-quality rabbit and guinea pig polyclonal antibodies, including both conjugated and unconjugated formats. These antibodies are validated for use in multiple applications such as immunohistochemistry (IHC), immunofluorescence (IF), Western blotting (WB), and flow cytometry (FACS), enabling precise detection and characterization of microglial markers across experimental systems.

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FAQs

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

91 Results
  • Anti-Human C3aR (extracellular) Antibody
    Anti-Human C3aR (extracellular) Antibody
    A Rabbit Polyclonal Antibody to C3a Anaphylatoxin Receptor
    • Product Code: AAR-031
    • Short Description: A Rabbit Polyclonal Antibody to C3a Anaphylatoxin Receptor
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot
    • Target: C3a anaphylatoxin chemotactic receptor, C3a anaphylatoxin receptor, Complement component 3a receptor 1, C3a receptor, C3AR1, C3R1, AZ3B, HNFAG09
  • Anti-Human CX3CR1 (extracellular) Antibody
    Anti-Human CX3CR1 (extracellular) Antibody
    A Rabbit Polyclonal Antibody to CX3CR1 Chemokine Receptor
    • Product Code: ACR-059
    • Short Description: A Rabbit Polyclonal Antibody to CX3CR1 Chemokine Receptor
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot
    • Target: Fractalkine Receptor, CX3C chemokine receptor 1, C-X3-C CKR-1, C-X3-C motif chemokine receptor 1, GPR13, CMKBRL1, GPRV28, V28, G-protein coupled receptor 13, CCRL1, Beta chemokine receptor-like 1
  • Anti-Human CX3CR1 (extracellular)-FITC Antibody
    Anti-Human CX3CR1 (extracellular)-FITC Antibody
    A Rabbit Polyclonal Antibody to CX3CR1 Conjugated to the Fluorescent Dye FITC
    • Product Code: ACR-059-F
    • Short Description: A Rabbit Polyclonal Antibody to CX3CR1 Conjugated to the Fluorescent Dye FITC
    • Host: Rabbit
    • Label: FITC
    • Reactivity: Human
    • Applications: Live cell imaging, Flow cytometry
    • Target: Fractalkine Receptor, CX3C chemokine receptor 1, C-X3-C CKR-1, C-X3-C motif chemokine receptor 1, GPR13, CMKBRL1, GPRV28, V28, G-protein coupled receptor 13, CCRL1, Beta chemokine receptor-like 1
  • Anti-HVCN1 (extracellular) Antibody
    Anti-HVCN1 (extracellular) Antibody
    A rabbit polyclonal antibody to HVCN1 (extracellular)
    • Product Code: AHC-002
    • Short Description: A rabbit polyclonal antibody to HVCN1 (extracellular)
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot
    • Target: HVCN1
  • Anti-HVCN1 Antibody
    KO Validate'
    Anti-HVCN1 Antibody
    A Rabbit Polyclonal Antibody to HVCN1 Channel
    • Product Code: AHC-001
    • Short Description: A Rabbit Polyclonal Antibody to HVCN1 Channel
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Indirect flow cytometry, Western blot
    • Target: Hydrogen voltage-gated channel 1, HV1, Voltage sensor domain-only protein, VSOP
  • Anti-IBA1/AIF1 Antibody
    Anti-IBA1/AIF1 Antibody
    A Rabbit Polyclonal Antibody to IBA1/AIF1
    • Product Code: ACS-010
    • Short Description: A Rabbit Polyclonal Antibody to IBA1/AIF1
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Western blot, Immunofluorescence, Immunohistochemistry
    • Target: Ionized calcium-binding adapter molecule 1, Allograft Inflammatory Factor 1, MRF-1, Microglia response factor
  • Anti-KCNK13 (THIK-1) (extracellular) Antibody
    Anti-KCNK13 (THIK-1) (extracellular) Antibody
    A Rabbit Polyclonal Antibody to KCNK13 Channel
    • Product Code: APC-121
    • Short Description: A Rabbit Polyclonal Antibody to KCNK13 Channel
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot, Immunohistochemistry
    • Target: Potassium channel subfamily K member 13, Tandem pore domain halothane-inhibited K+ channel 1, K2P13.1
  • Anti-MERTK (extracellular) Antibody
    Anti-MERTK (extracellular) Antibody
    A Rabbit Polyclonal Antibody to MERTK Receptor
    • Product Code: ATR-033
    • Short Description: A Rabbit Polyclonal Antibody to MERTK Receptor
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Indirect flow cytometry, Western blot, Immunofluorescence, Immunohistochemistry
    • Target: Receptor tyrosine kinase MerTK, C-Mer Proto-Oncogene Tyrosine Kinase, Mer, Proto-Oncogene C-Mer
  • Anti-MERTK (extracellular)-FITC Antibody
    Anti-MERTK (extracellular)-FITC Antibody
    A Rabbit Polyclonal Antibody to MERTK (extracellular) conjugated to the fluorescent dye FITC
    • Product Code: ATR-033-F
    • Short Description: A Rabbit Polyclonal Antibody to MERTK (extracellular) conjugated to the fluorescent dye FITC
    • Host: Rabbit
    • Label: FITC
    • Reactivity: Human, Rat, Mouse
    • Applications: Live cell imaging, Flow cytometry
    • Target: Receptor tyrosine kinase MerTK, C-Mer Proto-Oncogene Tyrosine Kinase, Mer, Proto-Oncogene C-Mer
  • Anti-P2X4 Receptor (extracellular) Antibody
    Anti-P2X4 Receptor (extracellular) Antibody
    A Rabbit Polyclonal Antibody to P2X4 Receptor
    • Product Code: APR-024
    • Short Description: A Rabbit Polyclonal Antibody to P2X4 Receptor
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
    • Target: P2RX4, P2X purinoceptor 4, ATP receptor
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