Microglia Markers

Microglia Markers

Microglia are the resident immune cells of the central nervous system (CNS). They originate from yolk sac progenitors during embryonic development and serve as the brain’s primary innate immune defense. In the healthy CNS, microglia continuously survey the microenvironment, contributing to synaptic pruning, neurogenesis, and tissue homeostasis. Upon injury, infection, or neurodegeneration, they become activated and undergo morphological and functional changes, including cytokine release, phagocytosis, and antigen presentation.

To support microglia research, Alomone Labs offers a wide range of high-quality rabbit and guinea pig polyclonal antibodies, including both conjugated and unconjugated formats. These antibodies are validated for use in multiple applications such as immunohistochemistry (IHC), immunofluorescence (IF), Western blotting (WB), and flow cytometry (FACS), enabling precise detection and characterization of microglial markers across experimental systems.

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FAQs

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

91 Results
  • Anti-TRPM2 Antibody
    KO Validate'
    Anti-TRPM2 Antibody
    A Rabbit Polyclonal Antibody to TRPM2 Channel
    • Product Code: ACC-043
    • Short Description: A Rabbit Polyclonal Antibody to TRPM2 Channel
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
    • Target: Transient receptor potential cation channel subfamily M member 2, LTrpC2, TrpC7
  • Anti-TRPM2-ATTO Fluor-594 Antibody
    KO Validate'
    Anti-TRPM2-ATTO Fluor-594 Antibody
    A Rabbit Polyclonal Antibody to TRPM2 Channel Conjugated to the Fluorescent Dye ATTO-594
    • Product Code: ACC-043-AR
    • Short Description: A Rabbit Polyclonal Antibody to TRPM2 Channel Conjugated to the Fluorescent Dye ATTO-594
    • Host: Rabbit
    • Label: ATTO 594
    • Reactivity: Human, Rat, Mouse
    • Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry
    • Target: Transient receptor potential cation channel subfamily M member 2, LTrpC2, TrpC7
  • Anti-TRPV2 (VRL1) (extracellular) Antibody
    Anti-TRPV2 (VRL1) (extracellular) Antibody
    A Rabbit Polyclonal Antibody to TRPV2 (VRL1) Channel
    • Product Code: ACC-039
    • Short Description: A Rabbit Polyclonal Antibody to TRPV2 (VRL1) Channel
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Immunohistochemistry
    • Target: Transient receptor potential cation channel subfamily V member 2, Vanilloid receptor-like protein 1, VRL-1, Osm-9-like TRP channel 2, OTRPC2, Stretch-activated channel 2B, SAC2B
  • Anti-TRPV2 (VRL1) (extracellular)-APC Antibody
    Anti-TRPV2 (VRL1) (extracellular)-APC Antibody
    A Rabbit Polyclonal Antibody to TRPV2 (VRL1) (extracellular) conjugated to the fluorescent dye Allophycocyanin (APC)
    • Product Code: ACC-039-APC
    • Short Description: A Rabbit Polyclonal Antibody to TRPV2 (VRL1) (extracellular) conjugated to the fluorescent dye Allophycocyanin (APC)
    • Host: Rabbit
    • Label: APC
    • Reactivity: Rat, Mouse
    • Applications: Live cell imaging, Flow cytometry
    • Target: Transient receptor potential cation channel subfamily V member 2, Vanilloid receptor-like protein 1, VRL-1, Osm-9-like TRP channel 2, OTRPC2, Stretch-activated channel 2B, SAC2B
  • Anti-TRPV2 (VRL1) (extracellular)-FITC Antibody
    Anti-TRPV2 (VRL1) (extracellular)-FITC Antibody
    A Rabbit Polyclonal Antibody to TRPV2 (VRL1) Channel Conjugated to the Fluorescent Dye FITC
    • Product Code: ACC-039-F
    • Short Description: A Rabbit Polyclonal Antibody to TRPV2 (VRL1) Channel Conjugated to the Fluorescent Dye FITC
    • Host: Rabbit
    • Label: FITC
    • Reactivity: Rat, Mouse
    • Applications: Flow cytometry
    • Target: Transient receptor potential cation channel subfamily V member 2, Vanilloid receptor-like protein 1, VRL-1, Osm-9-like TRP channel 2, OTRPC2, Stretch-activated channel 2B, SAC2B
  • Anti-TRPV2 (VRL1) Antibody
    Anti-TRPV2 (VRL1) Antibody
    A Rabbit Polyclonal Antibody to TRPV2 (VRL1) Channel
    • Product Code: ACC-032
    • Short Description: A Rabbit Polyclonal Antibody to TRPV2 (VRL1) Channel
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Western blot, Immunofluorescence, Immunoprecipitation, Immunohistochemistry
    • Target: Transient receptor potential cation channel subfamily V member 2, Vanilloid receptor-like protein 1, VRL-1, Osm-9-like TRP channel 2, OTRPC2, Stretch-activated channel 2B, SAC2B
  • Guinea pig Anti-EMR1 (ADGRE1) (extracellular) Antibody
    Guinea pig Anti-EMR1 (ADGRE1) (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to EMR1
    • Product Code: AER-051-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to EMR1
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot
    • Target: MR1 hormone receptor, EGF-like module-containing mucin-like hormone receptor-like 1, Adhesion G protein-coupled receptor E1, TM7LN3, F4/80, GPF480
  • Guinea Pig Anti-IBA1/AIF1 Antibody
    Guinea Pig Anti-IBA1/AIF1 Antibody
    A Guinea Pig Polyclonal Antibody to IBA1/AIF1
    • Product Code: ACS-010-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to IBA1/AIF1
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: Ionized calcium-binding adapter molecule 1, Allograft Inflammatory Factor 1, MRF-1, Microglia response factor
  • Guinea pig Anti-P2X4 Receptor Antibody
    Guinea pig Anti-P2X4 Receptor Antibody
    A Guinea Pig Polyclonal Antibody to P2X4 Receptor
    • Product Code: APR-002-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to P2X4 Receptor
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot
    • Target: P2RX4, P2X purinoceptor 4, ATP receptor
  • Guinea pig Anti-P2Y12 Receptor (extracellular) Antibody
    Guinea pig Anti-P2Y12 Receptor (extracellular) Antibody
    A Guinea Pig Polyclonal Antibody to P2Y12 Receptor
    • Product Code: APR-020-GP
    • Short Description: A Guinea Pig Polyclonal Antibody to P2Y12 Receptor
    • Host: Guinea Pig
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Live cell imaging, Western blot, Immunocytochemistry, Immunofluorescence, Immunohistochemistry
    • Target: P2Y purinoceptor 12, P2RY12, ADP-glucose receptor, Platelet ADP receptor, HORK3
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