Piezo Channels

Piezo Channels

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

9 Results
  • Anti-Piezo1 (extracellular) Antibody
    KO Validate'
    Anti-Piezo1 (extracellular) Antibody
    A Rabbit Polyclonal Antibody to Piezo1 Channel
    • Product Code: APC-087
    • Short Description: A Rabbit Polyclonal Antibody to Piezo1 Channel
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Rat, Mouse
    • Applications: Indirect flow cytometry, Live cell imaging, Western blot, Immunofluorescence, Immunohistochemistry
    • Target: Piezo-type mechanosensitive ion channel component 1, Protein FAM38A, Mib, Membrane protein induced by beta-amyloid treatment
  • Anti-Piezo1 (extracellular)-APC Antibody
    Anti-Piezo1 (extracellular)-APC Antibody
    A Rabbit Polyclonal Antibody to Piezo1 (extracellular) conjugated to the fluorescent dye Allophycocyanin (APC)
    • Product Code: APC-087-APC
    • Short Description: A Rabbit Polyclonal Antibody to Piezo1 (extracellular) conjugated to the fluorescent dye Allophycocyanin (APC)
    • Host: Rabbit
    • Label: APC
    • Reactivity: Rat, Mouse
    • Applications: Live cell imaging, Flow cytometry
    • Target: Piezo-type mechanosensitive ion channel component 1, Protein FAM38A, Mib, Membrane protein induced by beta-amyloid treatment
  • Anti-Piezo1 (extracellular)-FITC Antibody
    Anti-Piezo1 (extracellular)-FITC Antibody
    A Rabbit Polyclonal Antibody to Piezo1 (extracellular) conjugated to the fluorescent dye FITC
    • Product Code: APC-087-F
    • Short Description: A Rabbit Polyclonal Antibody to Piezo1 (extracellular) conjugated to the fluorescent dye FITC
    • Host: Rabbit
    • Label: FITC
    • Reactivity: Rat, Mouse
    • Applications: Live cell imaging, Flow cytometry
    • Target: Piezo-type mechanosensitive ion channel component 1, Protein FAM38A, Mib, Membrane protein induced by beta-amyloid treatment
  • Anti-Piezo2 Antibody
    KO Validate'
    Anti-Piezo2 Antibody
    A Rabbit Polyclonal Antibody to Piezo2
    • Product Code: APC-090
    • Short Description: A Rabbit Polyclonal Antibody to Piezo2
    • Host: Rabbit
    • Label: Unconjugated
    • Reactivity: Human, Rat, Mouse
    • Applications: Western blot, Immunohistochemistry
    • Target: Piezo-Type Mechanosensitive Ion Channel Component 2, Protein FAM38B
  • GsMTx-4
    Bioassay Tested
    GsMTx-4
    A potent inhibitor of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Product Code: STG-100
    • Short Description: A potent inhibitor of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Applications: Electrophysiology
    • CAS No.: 1209500-46-8
    • MW: 4096 Da
  • GsMTx-4-ATTO Fluor-647N
    Bioassay Tested
    GsMTx-4-ATTO Fluor-647N
    A fluorescent probe for imaging and sensitive detection of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Product Code: STG-100-FRN
    • Short Description: A fluorescent probe for imaging and sensitive detection of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Label: ATTO 647N
    • Applications: Electrophysiology, Direct flow cytometry, Fluorescence staining, Live cell imaging, Immunofluorescence
    • MW: 4723 Da
  • GsMTx-4-Biotin
    Bioassay Tested
    GsMTx-4-Biotin
    A biotinylated probe for the detection and imaging of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Product Code: STG-100-B
    • Short Description: A biotinylated probe for the detection and imaging of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Label: Biotin
    • Applications: Electrophysiology, Fluorescence staining, Live cell imaging, Immunofluorescence, Indirect flow cytometry
    • MW: 4435 Da
  • Piezo1 Blocking Peptide
    Piezo1 Blocking Peptide
    A Blocking Peptide for Anti-Piezo1 Antibody
    • Product Code: BLP-PC087
    • Short Description: A Blocking Peptide for Anti-Piezo1 Antibody
    • Applications: Western blot, Immunohistochemistry
    • Target: PIEZO1
  • Piezo2 Blocking Peptide
    Piezo2 Blocking Peptide
    A Blocking Peptide for Anti-Piezo2 Antibody
    • Product Code: BLP-PC090
    • Short Description: A Blocking Peptide for Anti-Piezo2 Antibody
    • Applications: Western blot, Immunohistochemistry
    • Target: PIEZO2
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