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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

8 Results
  • GsMTx-4-ATTO Fluor-647N
    Bioassay Tested
    GsMTx-4-ATTO Fluor-647N
    A fluorescent probe for imaging and sensitive detection of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Product Code: STG-100-FRN
    • Short Description: A fluorescent probe for imaging and sensitive detection of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Label: ATTO 647N
    • Applications: Electrophysiology, Direct flow cytometry, Fluorescence staining, Live cell imaging, Immunofluorescence
    • MW: 4723 Da
  • Wasabi Receptor Toxin
    Bioassay Tested
    Wasabi Receptor Toxin
    A cell-penetrating activator of TRPA1 channels
    • Product Code: STW-200
    • Short Description: A cell-penetrating activator of TRPA1 channels
    • Applications: Electrophysiology
    • CAS No.: 2569291-86-5
    • MW: 3855.3 Da
  • ProTx-I
    Bioassay Tested
    ProTx-I
    A blocker/gating modifier of NaV, CaV3.1, KV2.1 and TRPA1 channels
    • Product Code: STP-400
    • Short Description: A blocker/gating modifier of NaV, CaV3.1, KV2.1 and TRPA1 channels
    • Applications: Electrophysiology
    • CAS No.: 484598-35-8
    • MW: 3987.6 Da
  • GsMTx-4-Biotin
    Bioassay Tested
    GsMTx-4-Biotin
    A biotinylated probe for the detection and imaging of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Product Code: STG-100-B
    • Short Description: A biotinylated probe for the detection and imaging of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Label: Biotin
    • Applications: Electrophysiology, Fluorescence staining, Live cell imaging, Immunofluorescence, Indirect flow cytometry
    • MW: 4435 Da
  • GsMTx-4
    Bioassay Tested
    GsMTx-4
    A potent inhibitor of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Product Code: STG-100
    • Short Description: A potent inhibitor of mechanosensitive ion channels (Piezo1, TRPC1, TRPC6) and NaV1.7 sodium channels
    • Applications: Electrophysiology
    • CAS No.: 1209500-46-8
    • MW: 4096 Da
  • DkTx-K2
    Bioassay Tested
    DkTx-K2
    A reversible activator of TRPV1 channels
    • Product Code: STD-020
    • Short Description: A reversible activator of TRPV1 channels
    • Applications: Electrophysiology
    • MW: 3675.3 Da
  • DkTx-ATTO Fluor-647N
    Bioassay Tested
    DkTx-ATTO Fluor-647N
    A fluorescent probe for imaging and sensitive detection of TRPV1 Channel
    • Product Code: STD-010-FRN
    • Short Description: A fluorescent probe for imaging and sensitive detection of TRPV1 Channel
    • Label: ATTO 647N
    • Applications: Direct flow cytometry, Fluorescence staining, Live cell imaging, Immunofluorescence
    • MW: 9155 Da
  • DkTx
    Bioassay Tested
    DkTx
    A potent, nearly irreversible activator of TRPV1 channels
    • Product Code: STD-010
    • Short Description: A potent, nearly irreversible activator of TRPV1 channels
    • Applications: Electrophysiology
    • MW: 8529 Da
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