Epilepsy

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  • The expected molecular weight (MW) listed in the product datasheet is based solely on the size of the target protein’s amino acid sequence. It’s important to remember that many factors can affect the banding pattern of your western blot including: (1) the existence of a splice variant, (2) the quality of the loaded sample, (3) the protein extraction method, and (4) the protein transfer conditions. To achieve accurate results, you may need to systematically adjust the protein extraction method or the protein transfer conditions.

    • If the band’s MW is below the expected MW it could be due to a splice variant with a slightly different MW.
      • Heat the samples at 70°C for 10 min.
      • Increase the transfer time.
    • If the band’s MW is above the expected MW, it could be due to post-translational modifications.
    • In either event, you should use a blocking peptide as a negative control.

  • Some toxins and peptides are soluble in DMSO; you can find this information in the product specification section. For these products, prepare a concentrated stock solution first.

    1. Centrifuge vial (10,000 x g, 5 minutes) before adding solvent.
    2. Dissolve the lyophilized reagent in DMSO. We recommend keeping a concentrated stock solution at 1-10 mM (100-1000X higher than the final working concentration).
    3. Once the peptide is completely dissolved in DMSO, slowly dilute the peptide in pure water (or buffer) to the desired final working concentration.

    Note: We recommend that you maintain a DMSO concentration as low as possible. For cell assays, a final concentration of 0.1–0.5% DMSO (v/v) is considered acceptable. For other experiments, 5% DMSO (v/v) is recommended; adjust this according to your experimental requirements.

  • FAQ 3FAQ 3FAQ 3FAQ 3

790 Results
  • ATPA
    Bioassay Tested
    ATPA
    A Potent and Selective Agonist of GluK1 Kainate Receptor
    • Product Code: A-480
    • Short Description: A Potent and Selective Agonist of GluK1 Kainate Receptor
    • CAS No.: 140158-50-5
    • MW: 228.25
  • ATX-II
    Bioassay Tested
    ATX-II
    A potent activator of voltage-gated sodium NaV channels that primarily targets cardiac NaV1.5 channels by delaying their fast inactivation
    • Product Code: STA-700
    • Short Description: A potent activator of voltage-gated sodium NaV channels that primarily targets cardiac NaV1.5 channels by delaying their fast inactivation
    • Applications: Electrophysiology
    • CAS No.: 60748-45-0
    • MW: 4935 Da
  • Azasetron
    Bioassay Tested
    Azasetron
    A Potent and Selective Antagonist of 5-HT3 Channels
    • Product Code: A-240
    • Short Description: A Potent and Selective Antagonist of 5-HT3 Channels
    • CAS No.: 123040-69-7
    • MW: 349.8
  • AZD-1332
    Bioassay Tested
    AZD-1332
    A Potent and Selective Inhibitor of TrkA, TrkB, TrkC Receptors
    • Product Code: A-495
    • Short Description: A Potent and Selective Inhibitor of TrkA, TrkB, TrkC Receptors
    • CAS No.: NA
    • MW: 391.8
  • BDS-I
    Bioassay Tested
    BDS-I
    A blocker of KV potassium channels and a modulator that slows the inactivation of NaV sodium channels (particularly NaV1.7)
    • Product Code: STB-400
    • Short Description: A blocker of KV potassium channels and a modulator that slows the inactivation of NaV sodium channels (particularly NaV1.7)
    • Applications: Electrophysiology
    • CAS No.: 207621-38-3
    • MW: 4708 Da
  • BDS-II
    Bioassay Tested
    BDS-II
    A potent gating modifier/blocker of KV3 potassium channels and a modulator of NaV1.7 sodium channels
    • Product Code: B-450
    • Short Description: A potent gating modifier/blocker of KV3 potassium channels and a modulator of NaV1.7 sodium channels
    • Applications: Electrophysiology
    • MW: 4776.4 Da
  • BeKm-1
    Bioassay Tested
    BeKm-1
    A potent and selective blocker of hERG (KV11.1) potassium channels
    • Product Code: STB-470
    • Short Description: A potent and selective blocker of hERG (KV11.1) potassium channels
    • Applications: Electrophysiology
    • CAS No.: 524962-01-4
    • MW: 4092 Da
  • Benidipine hydrochloride
    Bioassay Tested
    Benidipine hydrochloride
    A Dihydropyridine Blocker of Voltage-Gated Ca2+ Channels
    • Product Code: B-120
    • Short Description: A Dihydropyridine Blocker of Voltage-Gated Ca2+ Channels
    • CAS No.: 91599-74-5
    • MW: 542
  • Benzamil hydrochloride
    Bioassay Tested
    Benzamil hydrochloride
    An Inhibitor of Na+/Ca2+ Exchangers and a Blocker of ASIC, TRPP3 and TRPA1 Channels
    • Product Code: B-160
    • Short Description: An Inhibitor of Na+/Ca2+ Exchangers and a Blocker of ASIC, TRPP3 and TRPA1 Channels
    • CAS No.: 161804-20-2
    • MW: 356.21
  • Bilobalide
    Bioassay Tested
    Bilobalide
    An Antagonist of 5-HT3A and GABA(A) Receptors
    • Product Code: B-145
    • Short Description: An Antagonist of 5-HT3A and GABA(A) Receptors
    • CAS No.:  33570-04-6
    • MW: 326.3
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