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6′-Iodoresiniferatoxin

6’-IRTX

An Activator of TRPV1 Channel

Cat #: I-805
Alternative Name 6’-IRTX
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Euphorbia resinifera (Moroccan cactus).
    Source Semi-synthetic
    MW: 754.6
    Purity: >98%
    Effective concentration 50 nM - 1 μM.
    Structure
    Chemical name Resiniferonyl 20-(4-hydroxy-2-iodo-5-methoxyphenylacetate 9,13,14-ortho(phenylacetate).
    Molecular formula C37H39IO9.
    CAS No.: 335151-55-8
    Activity 6'-Iodoresiniferatoxin is a partial activator of TRPV1 (Vanilloid/Capsaicin receptor 1) channel1.
    References-Activity
    1. McDonnell, M.E. et al. (2002) Bioorg. Med. Chem. Lett. 12, 1189.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or six months at -20°C.
    Protect from light.
    Our bioassay
    • Alomone Labs 6'-Iodoresiniferatoxin induces Ca2+ influx via activation of TRPV1 expressed in HEK293 cells.
      Alomone Labs 6'-Iodoresiniferatoxin induces Ca2+ influx via activation of TRPV1 expressed in HEK293 cells.
      Cells were loaded with 2 mM fluo-3 AM and then stimulated with 6’-Iodoresiniferatoxin (#I-805). The left panel shows the intracellular Ca2+ levels 10 sec post stimulation with different concentrations of 6’-Iodoresiniferatoxin (ED50 = 0.8 μM) and plotted against drug concentration. The right panel shows intracellular Ca2+ levels before and after stimulation of cells with 2.5 μM 6’- Iodoresiniferatoxin.
    References - Scientific background
    1. McDonnell, M.E. et al. (2002) Bioorg. Med. Chem. Lett. 12, 1189.
    Scientific background 6’-Iodoresiniferatoxin is an agonist of the TRPV1 (Vanilloid/Capsaicin receptor) channel.1 It is an iodinated form of the potent agonist Resiniferatoxin (#R-400). It displayed high affinity binding (Ki=0.71 nM) for the human TRPV1 receptor and functioned as a partial agonist.1
    Target TRPV1 channels
    Lyophilized Powder
    Last update: 08/06/2021

    6’-Iodoresiniferatoxin (#I-805) is a highly pure, semi-synthetic, and biologically active compound.

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    For research purposes only, not for human use
    Shipping and Ordering information

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