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___ Cells + rabbit IgG isotype control-FITC.
___ Cells + Anti-Neuropilin-2 (extracellular)-FITC Antibody (ANR-062-F), (2.5 µg).
The neuropilins (Nrps) are single-pass multifunctional transmembrane glycoproteins that play an important role in cell development, immunity and cancer, physiological and pathological angiogenesis. They were first discovered as regulators of nervous system development, acting as semaphorin coreceptors with plexins and also enhance cellular responses to members of the vascular endothelial growth factor (VEGF) family.
They comprise of two members: Neuropilin-1 (NRP1) and Neuropilin-2 (NRP2) which are usually expressed as homodimers but also can appear as heterodimers. NRP2 contains a large N-terminal extracellular consisting of five domains, a short transmembrane domain and a small cytoplasmic domain1-3.
Nrp2 is expressed in a wide variety of cells including endothelial cells, neurons, pancreatic islet cells, hepatocytes, melanocytes and osteoblasts. Nrp2 has been shown to mediate proliferation, survival, and migration of tumor cells3.
Nrp2 knockout mice studies show that mice are viable without defects in blood vessels but display abnormal lymphatic development and defects of the central and peripheral nervous system2.
Species reactivity key:
Anti-Neuropilin-2 (extracellular) Antibody (#ANR-062) is a highly specific antibody directed against an epitope of the human protein. The antibody can be used in western blot, immunohistochemistry, and indirect flow cytometry applications. The antibody recognizes an extracellular epitope and is thus ideal for detecting the protein in living cells. It has been designed to recognize NRP2 from mouse, rat, and human samples.
Anti-Neuropilin-2 (extracellular)-FITC Antibody (#ANR-062-F) is directly conjugated to fluorescein isothiocyanate (FITC). This labeled antibody can be used in immunofluorescent applications such as direct live cell flow cytometry.