- Peptide (C)GSHPNSEKQRARRK, corresponding to amino acid residues 43-56 of rat ZnT2 (Accession Q62941). Intracellular, N-terminus.
- Western blot analysis of mouse kidney (lanes 1 and 3) and rat small intestine (lanes 2 and 4) lysates:1,2. Anti-ZnT2 (SLC30A2) Antibody (#AZT-012), (1:200).
3,4. Anti-ZnT2 (SLC30A2) Antibody, preincubated with ZnT2/SLC30A2 Blocking Peptide (#BLP-ZT012).
ZnT2 is a member of the SLC30 family of zinc transporters which promotes the influx of zinc ions into synaptic vesicles of glutamatergic neurons from the cytoplasm, intracellular organelles, or to the outside of the cell. ZnT2 is responsible for maintaining high intravesicular zinc content. In addition, ZnT2 also imports zinc into the mitochondria, which constricts ATP generation and activates apoptosis. ZnT2 is encoded by the Slc30a2 gene and functions as a homo- or heterodimer. The protein structure consists of six transmembrane domains with cytoplasmic N- and C-termini that contain multiple regulatory domains1.
Expression of ZnT2 is restricted to secretory cells, such as acinar pancreatic cells, prostate epithelial cells, placental trophoblasts, placenta, ovary and mammary epithelial cells1,2.
Studies show that eight missense mutations have been identified in the human SLC30A2 gene that lead to pathologically low breast milk Zn concentrations and severe zinc deficiency in breastfed infants, a disorder known as transient neonatal zinc deficiency1.
Species reactivity key:
Anti-ZnT2 (SLC30A2) Antibody (#AZT-012) is a highly specific antibody directed against an epitope of the rat Zinc transporter 2. The antibody can be used in western blot analysis. It has been designed to recognize ZnT2 from mouse and rat samples. It will not recognize the protein from human samples.