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Cannabichromene

Cannabichrome, Pentylcannabichromene, CBC

An Activator of TRPA1 Channels and an Antagonist of Cannabinoid Receptor 1 and TRPM8 Channels

Cat #: C-315
Alternative Name Cannabichrome, Pentylcannabichromene, CBC
  • Bioassay Tested
  • Source Synthetic
    MW: 314.5
    Purity: >98%
    Form Oily material.
    Effective concentration 10 nM - 100 µM.
    Structure
    • Please note, this product is available for sale in Israel only.
    Chemical name 2-methyl-2-(4-methylpent-3-enyl)-7-pentylchromen-5-ol.
    Molecular formula C21H30O2.
    CAS No.: 20675-51-8
    Activity CBC is an activator of TRPA1 with an EC50 of 90 nM and a blocker of TRPM8 with an IC50 of 40 µM1.
    References-Activity
    1. De Petrocellis, L. et al. (2001) Br. J. Pharmacol. 163, 1479.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Up 100 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Cannabichromene activates TRPA1 channels expressed in HEK-293 cells. 
      Alomone Labs Cannabichromene activates TRPA1 channels expressed in HEK-293 cells. 
      Dose-response curve for the activation of human TRPA1 expressing HEK-293 cells loaded with Calcium 5 dye for changes in intracellular Ca2+ measurements. Calcium signal was apparent with 5 µM Cannabichromene (#C-315).
    References - Scientific background
    1. De Petrocellis, L. et al. (2001) Br. J. Pharmacol. 163, 1479.
    2. Romano, B. et al. (2013) Br. J. Pharmacol. 169, 213.
    3. Russo, E.B. (2011) Br. J. Pharmacol. 163, 1344.
    Scientific background

    Cannabichromene (CBC) is a member of the cannabinoids, compounds derived from a diterpene structure origin of the marijuana plant Cannabis sativa, and particularly abundant in freshly harvested dry-type Cannabis material. These compounds have been used for over a 1000 years as medicinal agents for the relief of pain, as well as for recreational purposes1.

    CBC is a major non-psychotropic phytocannabinoid that inhibits endocannabinoid inactivation and activates the transient receptor potential ankyrin-1 (TRPA1) channels and enzymes of the endocannabinoid system. In addition, it also acts as a TRPM8 antagonist.

    CBC selectively reduces inflammation-induced hypermotility in vivo independently from cannabinoid receptors or TRPA11,2.

    Several studies have demonstrated that CBC exerts antimicrobial, anti-inflammatory, analgesic and antidepressant-like activity in rodents and has the ability to normalize in vivo intestinal motility in an experimental model of intestinal inflammation3.

    Cannabichromene potency tested induced TRPA1-mediated Ca2+ elevation showed efficacy of EC50 of 90 nM1.

    Target TRPA1, TRPM8 channels, Cannabinoid receptor 1
    Last update: 12/08/2021

    Cannabichromene (#C-315) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
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