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Forskolin

Colforsin, Coleonol

An Adenylate Cyclase Activator

Cat #: F-500
Alternative Name Colforsin, Coleonol
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Coleus forskohlii.
    Source Natural
    MW: 410.5
    Purity: >97% (HPLC)
    Effective concentration 5-10 μM.
    Structure
    Chemical name [3R-(3a,4ab,5b,6b,6aa,10a,10ab,10ba)]-5-(Acetyloxy)-3-e thenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pent amethyl-1H-naphtho[2,1-b]pyran-1-one.
    Molecular formula C22H34O7.
    CAS No.: 66575-29-9
    Activity Forskolin increases cAMP levels by activating adenylate cyclase1.
    References-Activity
    1. Awad, J.A. et al. (1983) J. Biol. Chem. 258, 2960.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility DMSO, ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four months at 4°C.
    Our bioassay
    • Alomone Labs Forskolin activates (in vivo) adenylate cyclase in NIH/C6 neuroblastoma cells.
      Alomone Labs Forskolin activates (in vivo) adenylate cyclase in NIH/C6 neuroblastoma cells.
      Cells were pre-incubated for 30 min with IBMX (10 mM) and then stimulated for 30 min with different concentrations of Forskolin (#F-500). Cellular cAMP levels were measured by an ELISA kit.
    References - Scientific background
    1. De Souza, N.J. (1993) J. Ethnopharmacol. 38, 177.
    2. Insel, P.A. et al. (2003) Cell Mol. Neurobiol. 23, 305.
    3. Hoffman, B.B. et al. (1987) Horm. Metab. Res. 19, 358.
    4. Mills, I. et al. (1984) Endocrinology 115, 1066.
    5. Christenson, J.T. et al. (1995) Vasa 24, 56.
    6. Hermansen, K. (1985) Endocrinology 116, 2251.
    7. Metzger, H. et al. (1981) Arzneimittelforschung 31, 1248.
    8. Schlepper, M. et al. (1989) Basic Res. Cardiol. 84 Suppl 1, 197.
    9. Hartzell, H.C. et al. (1992) Mol. Pharmacol. 41, 880.
    10. Li, X. et al. (1995) Am. J. Physiol. 269, C986.
    Scientific background Forskolin is a cell permeable diterpenoid isolated from Coleus forskohlii. Forskolin has a unique ability to stimulate adenylate cyclase activity and increase cyclic adenosine monophosphate (cAMP)1-10.
    Lyophilized Powder
    Last update: 02/01/2022

    Forskolin (#F-500) is a highly pure, natural, and biologically active compound.

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    For research purposes only, not for human use

    Applications

    Citations

    Citations
    Published figures using this product
    • Palma, A.G. et al. (2016) Pflugers Arch. 468, 871.

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