Cat #:
F-500
Alternative Name Colforsin, Coleonol
Lyophilized Powder yes
Every lot is tried & tested in a relevant biological assay.
Our Bioassay
Origin Coleus forskohlii.
Source Natural
MW: 410.5
Purity: >97% (HPLC)
Effective concentration 5-10 μM.
Chemical name [3R-(3a,4ab,5b,6b,6aa,10a,10ab,10ba)]-5-(Acetyloxy)-3-e thenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pent amethyl-1H-naphtho[2,1-b]pyran-1-one.
Molecular formula C22H34O7.
CAS No.: 66575-29-9
Activity Forskolin increases cAMP levels by activating adenylate cyclase1.
References-Activity
- Awad, J.A. et al. (1983) J. Biol. Chem. 258, 2960.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility DMSO, ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to four months at 4°C.
Our bioassay
References - Scientific background
- De Souza, N.J. (1993) J. Ethnopharmacol. 38, 177.
- Insel, P.A. et al. (2003) Cell Mol. Neurobiol. 23, 305.
- Hoffman, B.B. et al. (1987) Horm. Metab. Res. 19, 358.
- Mills, I. et al. (1984) Endocrinology 115, 1066.
- Christenson, J.T. et al. (1995) Vasa 24, 56.
- Hermansen, K. (1985) Endocrinology 116, 2251.
- Metzger, H. et al. (1981) Arzneimittelforschung 31, 1248.
- Schlepper, M. et al. (1989) Basic Res. Cardiol. 84 Suppl 1, 197.
- Hartzell, H.C. et al. (1992) Mol. Pharmacol. 41, 880.
- Li, X. et al. (1995) Am. J. Physiol. 269, C986.
Scientific background Forskolin is a cell permeable diterpenoid isolated from Coleus forskohlii. Forskolin has a unique ability to stimulate adenylate cyclase activity and increase cyclic adenosine monophosphate (cAMP)1-10.
Lyophilized Powder
Last update: 06/11/2022
Forskolin (#F-500) is a highly pure, natural, and biologically active compound.
For research purposes only, not for human use
Applications
Citations
Citations
Published figures using this product
- Palma, A.G. et al. (2016) Pflugers Arch. 468, 871.
Specifications
Scientific Background
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