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N-Me-aminopyrimidinone 9

A Specific Blocker of NaV1.7 Channel

Cat #: N-310
Lyophilized Powder yes
  • Bioassay Tested
    • Source Synthetic
    MW: 303.4
    Purity: >98%
    Effective concentration 10 nM - 1 µM.
    Structure
    Chemical name 6-amino-2-[(4-tert-butylphenyl)methylsulfanyl]-3-methylpyrimidin-4-one.
    Molecular formula C16H21N3OS.
    PubChem CID 56951318
    Activity N-Me-aminopyrimidinone 9 is a NaV1.7 channel blocker with IC50 value of 100 nM for NaV1.7 channels in their inactivated state1.
    References-Activity
    1. Nguyen, H.N. et al. (2012) Bioorg. Med. Chem. Lett. 22, 1055.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs N-Me-aminopyrimidinone 9 blocks NaV1.7 channels expressed in Xenopus oocytes.
      Alomone Labs N-Me-aminopyrimidinone 9 blocks NaV1.7 channels expressed in Xenopus oocytes.
      A. Time course of NaV1.7 current amplitude and inhibition by 100 nM N-Me-aminopyrimidinone 9 (#N-310). Currents were elicited by application of a 100 ms voltage step to 0 mV (H.P= -70 mV, to induce inactivation), every 10 seconds. B. Superimposed example traces of current responses before and during perfusion of 100 nM N-Me-aminopyrimidinone 9, as indicated.
    References - Scientific background
    1. Nguyen, H.N. et al. (2012) Bioorg. Med. Chem. Lett. 22, 1055.
    Scientific background

    N-Me-aminopyrimidinone 9, is a synthetic blocker of NaV1.7 channel. It has an effective concentration of 10 nM – 1 μM and an IC50 of 100 nM for NaV1.7 channel in its inactive state.

    NaV channels contribute to physiological and pathophysiological electrical signaling in nerve and muscle cells. NaV1.7 is highly expressed on the exons somatic afferent neurons and is thought to play an important role in the signaling of inflammatory pain.

    Target NaV1.7 channels
    Lyophilized Powder
    Last update: 11/04/2021

    N-Me-aminopyrimidinone 9 (#N-310) is a highly pure, synthetic, and biologically active compound.

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    For research purposes only, not for human use
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