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Penitrem A

Tremortin A

A Blocker of KCa1.1 (BK) Channels

Cat #: P-650
Alternative Name Tremortin A
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Penicillium palitans.
    Source Natural
    MW: 634.2
    Purity: >98%
    Effective concentration 10-100 nM.
    Structure
    Molecular formula C37H44ClNO6.
    CAS No.: 12627-35-9
    Activity Penitrem A is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels1. Penitrem A increases the spontaneous release of endogenous GABA (3-aminobutyric acid), and aspartate2.
    References-Activity
    1. Hollywood, M. A. et al. (2000) Am. J. Physiol. 279, C420.
    2. Norris, P.J. et al. (1980) J. Neurochem. 34, 33.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility DMSO, methanol, acetone. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to one week at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Penitrem A inhibits KCa1.1 (BK) channels heterologously expressed in Xenopus oocytes.
      Alomone Labs Penitrem A inhibits KCa1.1 (BK) channels heterologously expressed in Xenopus oocytes.
      The effect of 100 nM Paxilline (#P-450) (a), Penitrem A (#P-650) (b) and Verruculogen (#V-500) (c) on BK currents. Time course of current amplitude changes upon sequential application of the three toxins.
    References - Scientific background
    1. Hollywood, M. A. et al. (2000) Am. J. Physiol. 279, C420.
    2. Knaus, H. G. et al. (1994) Biochemistry 33, 5819.
    3. Norris, P.J. et al. (1980) J. Neurochem. 34, 33.
    Scientific background Penitrem A is widely used to probe KCa1.1 channels in smooth muscle preparations, where it induces prolongation of the depolarization plateau potential.1 Penitrem A is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Verruculogen (#V-500) and Paxilline (#P-450).2 Penitrem A (400 mg mycelium/kg) increased the spontaneous release of endogenous glutamate, GABA (γ-aminobutyric acid), and aspartate by 213%, 455%, and 277%, respectively, from rat cerebrocortical synaptosomes.3
    Target KCa1.1 K+ channels
    Lyophilized Powder
    Last update: 13/10/2022

    Penitrem A (#P-650) is a highly pure, natural, and biologically active compound.

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    For research purposes only, not for human use

    Applications

    Citations

    Citations
    Product citations
    1. Ishii, H. et al. (2010) Eur. J. Neurosci. 32, 736.
    2. Rancz, E.A. and Häusser, M. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 22284.
    3. Donato, R. et al. (2006) J. Neurosci. 26, 12576.
    4. Rancz, E.A. and Häusser, M. (2006) J. Neurosci. 26, 5428.

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