Cat #: P-650
Alternative Name Tremortin A
Lyophilized Powder yes
Every lot is tried & tested in a relevant biological assay.
Origin Penicillium palitans.
Effective concentration 10-100 nM.
Molecular formula C37H44ClNO6.
CAS No.: 12627-35-9
Activity Penitrem A is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels1. Penitrem A increases the spontaneous release of endogenous GABA (3-aminobutyric acid), and aspartate2.
Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Solubility DMSO, methanol, acetone. Centrifuge all product preparations before use (10000 x g 5 min).
Storage of solutions Up to one week at 4°C or three months at -20°C.
- Alomone Labs Penitrem A inhibits KCa1.1 (BK) channels heterologously expressed in Xenopus oocytes.
References - Scientific background
Scientific background Penitrem A is widely used to probe KCa1.1 channels in smooth muscle preparations, where it induces prolongation of the depolarization plateau potential.1 Penitrem A is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Verruculogen (#V-500) and Paxilline (#P-450).2 Penitrem A (400 mg mycelium/kg) increased the spontaneous release of endogenous glutamate, GABA (γ-aminobutyric acid), and aspartate by 213%, 455%, and 277%, respectively, from rat cerebrocortical synaptosomes.3
Target KCa1.1 K+ channels
Last update: 12/08/2021
Penitrem A (#P-650) is a highly pure, natural, and biologically active compound.
For research purposes only, not for human use
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