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Triacsin C

An Acyl CoA Synthase Inhibitor

Cat #: T-750
Lyophilized Powder yes
  • Bioassay Tested
    • Origin Streptomyces aureofaciens.
    Source Natural
    MW: 207.3
    Purity: >94%
    Effective concentration >10 nM.
    Structure
    Chemical name N-[(E)-[(2E,4E,7E)-undeca-2,4,7- trienylidene]amino]nitrous amide.
    Molecular formula C11H17N3O.
    CAS No.: 76896-80-5
    Activity Triacsin C nearly completely inhibits de novo synthesis of triacylglycerol and phospholipids1,2.
    References-Activity
    1. Omura, S. et al. (1986) J. Antibiot. (Tokyo) 39, 1211.
    2. Tomoda, H. et al. (1987) Biochim. Biophys. Acta 17, 595.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to two weeks at 4°C or six months at -20°C.
    Protect from light.
    Our bioassay
    • Alomone Labs Triacsin C inhibits the proliferation of 3T3-L1 cells.
      Alomone Labs Triacsin C inhibits the proliferation of 3T3-L1 cells.
      Cells were treated with different concentrations of Triacsin C (#T-750) for 3 days. The number of live cells was measured by XTT cell proliferation assay kit, normalized to the control (100%) and plotted against the drug concentration.
    References - Scientific background
    1. Yoshida, K. et al. (1982) J. Antibiot. (Tokyo) 35, 151.
    2. Omura, S. et al. (1986) J. Antibiot. (Tokyo) 39, 1211.
    3. Tomoda, H. et al. (1987) Biochim. Biophys. Acta. 17, 595.
    4. Tomoda, H. et al.  (1991) J. Biol. Chem. 266, 4214.
    5. Hartman, E.J. et al. (1989) Prostaglandins 37, 655.
    Scientific background

    Triacsin C is a fungal metabolite from Streptomyces aureofaciens1 which almost completely inhibits de novo synthesis of triacylglycerol and phospholipid.2,3 This compound specifically inhibits the activity of long chain acyl-CoA synthetase 1 and 4 (IC50~8µM) but has no effect on the activity of acyl-CoA synthetase 5, in intact cells and in cell lysates. Inhibition of these enzymes causes a decrease in the cellular levels of acyl-CoA precursors for lipid synthesis activity, cell proliferation and lipid transformation.4 Kinetic analysis indicates that inhibition of acyl-CoA synthetase by Triacsin C is not competitive with respect to the two substrates of acyl-CoA synthetase (ATP and coenzyme A), but is competitive with respect to long-chain fatty acids. The N-hydroxytriazene moiety of Triacsin C has been suggested to be essential for the inhibitory activity against acyl-CoA synthetase.2-4

    Triacsin C arrests the metabolism of arachidonic acid by inhibition of arachidonoyl-CoA synthetase thus interfering in the production of prostaglandins and in the regulation of blood pressure.5

    Lyophilized Powder
    Last update: 13/10/2022

    Triacsin C (#T-750) is a highly pure, natural, and biologically active compound.

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    For research purposes only, not for human use

    Applications

    Citations

    Citations
    Product citations
    1. Narita, T. et al. (2016) Sci. Rep. 6, 25469.
    2. Araujo, J.R. et al. (2013) J. Nutr. Biochem. 24, 1741.

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