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Ambien, Zolpidemum, Lorex

An Agonist of GABA(A) Receptors

Cat #: Z-100
Alternative Name Ambien, Zolpidemum, Lorex
Lyophilized Powder yes
  • Bioassay Tested
  • Source Synthetic
    MW: 307.39
    Purity: >99%
    Effective concentration 0.1-100 nM.
    Chemical name N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide.
    Molecular formula C19H21N3O.
    CAS No.: 82626-48-0
    PubChem CID 5732
    Activity GABA(A) receptor agonist at the benzodiazepine site, potent and highly selective for α1-subunit-containing receptors (EC50 = 47.8 nM on α1β1γ2L)1.
    1. Horne, A.L. et. al. (1992) Br. J. Pharmacol. 107, 732.
    Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
    Solubility Up to 100 mM in Ethanol and 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
    Storage of solutions Up to four weeks at 4°C or three months at -20°C.
    Our bioassay
    • Alomone Labs Zolpidem inhibits specific binding of Ro-15-1788 to cerebellum GABA(A) receptors.
      Alomone Labs Zolpidem inhibits specific binding of Ro-15-1788 to cerebellum GABA(A) receptors.
      Percent inhibition of specific binding of 1 nM [3H] Ro-15-1788 to membranes from rat cerebellum, plotted against increasing concentrations of Zolpidem (#Z-100). Full inhibition is achieved at over 50 nM.
    References - Scientific background
    1. Herrmann, E.S. et al. (2016) Psychopharmacology 233, 2469.
    2. Park, S.M. et al. (2016) Osteoporos. Int. 27, 2935.
    Scientific background

    Zolpidem (Ambien, Lorex) is a synthetic agonist of GABA(A) receptors. Zolpidem is highly selective for α1-subunit containing receptors and has an EC50 of 47.8 nM on α1β1γ2L. Zolpidem is used for the treatment of cannabis use disorder (CUD). It decreases withdrawal related disruptions in sleep, and in combination with nabilone, decreases withdrawal-related disruptions in mood and food intake relative to placebo. In addition, the combination of the two drugs causes decreased self-administration of active cannabis1.

    Zolpidem is a popular treatment in the US and Asia for the treatment of insomnia. It has a quick onset of 15 minutes, a short half-life (2-3 hours) and it preserves sleep patterns better than other medications of its type. However, it can cause side effects such as dizziness, confusion, impaired motor coordination and postural imbalance. A recent meta-analysis published shows that Zolpidem use is associated with increased risk of fracture due to the aforementioned side effects2.

    Target GABA(A) receptors
    Last update: 25/07/2021

    Zolpidem (#Z-100) is a highly pure, synthetic, and biologically active compound.

    For research purposes only, not for human use
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